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CATH Superfamily 3.30.420.40

ATPase, nucleotide binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 79206: Hexokinase 1, isoform CRA_f

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hexokinase. [EC: 2.7.1.1]
ATP + D-hexose = ADP + D-hexose 6-phosphate.
  • D-glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors.
  • ITP and dATP can act as donors.
 192 A0A024R7R1 A0A024R7R1 A0A024R7R1 A0A024R7R1 A0A061IEL2 A0A061IEL2 A0A086K2D1 A0A086K2D1 A0A086KCI0 A0A086KCI0
(182 more...)
Glucokinase. [EC: 2.7.1.2]
ATP + D-glucose = ADP + D-glucose 6-phosphate.
  • A group of enzymes found in invertebrates and microorganisms highly specific for glucose.
 32 A0A0F8DP44 A0A0F8DP44 C8Z449 C8Z449 G2WBP3 G2WBP3 G3XWC9 G3XWC9 N1P652 N1P652
(22 more...)
4-hydroxy-4-methyl-2-oxoglutarate aldolase. [EC: 4.1.3.17]
(1) 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. (2) 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate.
  • This enzyme participates in the degradation of protocatechuate (via the meta-cleavage pathway), phthalate, syringate and gallate.
  • The enzyme from Pseudomonas ochraceae can also cleave 4-hydroxy-2- oxoglutarate to glyoxylate and pyruvate, and also catalyzes the reaction of EC 4.1.1.3.
 12 A0A0D3ETH5 A0A0D3ETH5 A0A0D9YEC2 A0A0D9YEC2 A0A0E0FSG7 A0A0E0FSG7 A0A0E0JNF0 A0A0E0JNF0 A0A0E0JNF1 A0A0E0JNF1
(2 more...)
Oxaloacetate decarboxylase. [EC: 4.1.1.3]
Oxaloacetate = pyruvate + CO(2).
  • The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA.
  • The process is accompanied by the extrusion of two sodium ions from cells.
  • Some animal enzymes require manganese.
 12 A0A0D3ETH5 A0A0D3ETH5 A0A0D9YEC2 A0A0D9YEC2 A0A0E0FSG7 A0A0E0FSG7 A0A0E0JNF0 A0A0E0JNF0 A0A0E0JNF1 A0A0E0JNF1
(2 more...)
Hydroxymethylglutaryl-CoA reductase (NADPH). [EC: 1.1.1.34]
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
  • The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.
 2 L8X6U2 L8X6U2
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