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CATH Superfamily 3.30.420.40

ATPase, nucleotide binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 77117: Actin, gamma-enteric smooth muscle

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Isopentenyl-diphosphate Delta-isomerase. [EC: 5.3.3.2]
Isopentenyl diphosphate = dimethylallyl diphosphate.
    		 42 A0A067QL86 A0A067QL86 A0A0A9W354 A0A0A9W354 A0A0P4VVE9 A0A0P4VVE9 A0A0P5CHV2 A0A0P5CHV2 A0A0V0G386 A0A0V0G386
    (32 more...)
    NAD(+) ADP-ribosyltransferase. [EC: 2.4.2.30]
    NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
    • The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
    		 2 M7BV04 M7BV04
    Deleted entry. [EC: 3.1.2.15]
      		2 A0A061HZ54 A0A061HZ54
      Deoxyhypusine synthase. [EC: 2.5.1.46]
      [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
      • The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity.
      • Catalyzes the first reaction of hypusine formation from one specific lysine residue of the eIF5A precursor.
      • The reaction occurs in four steps: NAD(+)-dependent dehydrogenation of spermidine (1a), formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (1b), transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor (1c), reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue (1d).
      • Hence the overall reaction is transfer of a 4-aminobutyl group.
      • For the plant enzyme, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor.
      • Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29.
      • Formerly EC 1.1.1.249.
      		 2 B3LAP0 B3LAP0
      Non-specific protein-tyrosine kinase. [EC: 2.7.10.2]
      ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
      • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
      • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
      • Formerly EC 2.7.1.112.
      		 2 P00544 P00544