The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 27968: Hexokinase 1, isoform CRA_d

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hexokinase activity GO:0004396
Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
4 O08528 (/IDA) P05708 (/IDA) P17710 (/IDA) P27881 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P05708 (/IPI) P17710 (/IPI) P19367 (/IPI) P52789 (/IPI)
Hexokinase activity GO:0004396
Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
3 P17710 (/TAS) P19367 (/TAS) P52789 (/TAS)
Glucokinase activity GO:0004340
Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.
2 P05708 (/IDA) P17710 (/IDA)
Glucokinase activity GO:0004340
Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.
2 P19367 (/TAS) P52789 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 P05708 (/IDA) P27881 (/IDA)
Glucose binding GO:0005536
Interacting selectively and non-covalently with the D- or L-enantiomer of glucose.
2 P05708 (/IDA) P27881 (/IDA)
Hexokinase activity GO:0004396
Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
1 O08528 (/IMP)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P05708 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P05708 (/IC)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 P05708 (/IC)
Protein complex binding GO:0032403
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P05708 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P05708 (/IDA)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
3 P17710 (/TAS) P19367 (/TAS) P52789 (/TAS)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
2 P05708 (/IDA) P27881 (/IDA)
Glucose transport GO:0015758
The directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P19367 (/TAS) P52789 (/TAS)
Carbohydrate phosphorylation GO:0046835
The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.
2 P05708 (/IDA) P27881 (/IDA)
Canonical glycolysis GO:0061621
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.
2 P19367 (/TAS) P52789 (/TAS)
Establishment of protein localization to mitochondrion GO:0072655
The directed movement of a protein to the mitochondrion or a part of the mitochondrion.
2 P19367 (/IMP) P52789 (/IMP)
Establishment of protein localization to mitochondrion GO:0072655
The directed movement of a protein to the mitochondrion or a part of the mitochondrion.
2 O08528 (/ISO) P17710 (/ISO)
Maintenance of protein location in mitochondrion GO:0072656
Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere.
2 P19367 (/IMP) P52789 (/IMP)
Maintenance of protein location in mitochondrion GO:0072656
Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere.
2 O08528 (/ISO) P17710 (/ISO)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 O08528 (/IMP)
Glucose catabolic process GO:0006007
The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.
1 P27881 (/TAS)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
1 P05708 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P05708 (/IDA)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
1 P27881 (/IEP)
Apoptotic mitochondrial changes GO:0008637
The morphological and physiological alterations undergone by mitochondria during apoptosis.
1 P52789 (/IDA)
Apoptotic mitochondrial changes GO:0008637
The morphological and physiological alterations undergone by mitochondria during apoptosis.
1 O08528 (/IGI)
Apoptotic mitochondrial changes GO:0008637
The morphological and physiological alterations undergone by mitochondria during apoptosis.
1 O08528 (/ISO)
Response to brassinosteroid GO:0009741
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus.
1 P05708 (/IEP)
Regulation of anion channel activity GO:0010359
Any process that modulates the frequency, rate or extent of anion channel activity.
1 P05708 (/IDA)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 P05708 (/IDA)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
1 P05708 (/IDA)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
1 P05708 (/IDA)
Negative regulation of mitochondrial membrane permeability GO:0035795
Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
1 O08528 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P05708 (/IMP)
Regulation of glucose import GO:0046324
Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
1 O08528 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P05708 (/IDA)
Carbohydrate phosphorylation GO:0046835
The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.
1 O08528 (/IMP)
Canonical glycolysis GO:0061621
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.
1 P17710 (/IC)
Response to ketamine GO:1901986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus.
1 P05708 (/IEP)
Positive regulation of mitophagy in response to mitochondrial depolarization GO:1904925
Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization.
1 P52789 (/IMP)
Positive regulation of mitophagy in response to mitochondrial depolarization GO:1904925
Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization.
1 O08528 (/ISO)
Negative regulation of reactive oxygen species metabolic process GO:2000378
Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
1 O08528 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 A0A024QZK7 (/IDA) O08528 (/IDA) P05708 (/IDA) P17710 (/IDA) P19367 (/IDA) P27881 (/IDA) Q2TB90 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P17710 (/ISO) Q91W97 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P05708 (/IDA) P17710 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P19367 (/TAS) P52789 (/TAS)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 P52789 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 O08528 (/ISO)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 P52789 (/NAS)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 P27881 (/TAS)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 P05708 (/IDA)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 P17710 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P52789 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O08528 (/ISO)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
1 P05708 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P17710 (/IDA)
Sperm principal piece GO:0097228
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
1 P17710 (/IDA)