The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Ribonuclease H-like superfamily/Ribonuclease H
".
FunFam 45985: Pol polyprotein
There are 8 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
RNA-directed DNA polymerase.
[EC: 2.7.7.49]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
218 |
H9BTT0
H9BTT0
H9BTT1
H9BTT1
H9BTT2
H9BTT2
O12158
O12158
O41798
O41798 (208 more...) |
DNA-directed DNA polymerase.
[EC: 2.7.7.7]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
152 |
O12158
O12158
O41798
O41798
O89290
O89290
O89940
O89940
O91080
O91080 (142 more...) |
Retroviral ribonuclease H.
[EC: 3.1.26.13]
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
|
146 |
O12158
O12158
O41798
O41798
O89290
O89290
O89940
O89940
O91080
O91080 (136 more...) |
Exoribonuclease H.
[EC: 3.1.13.2]
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
|
146 |
O12158
O12158
O41798
O41798
O89290
O89290
O89940
O89940
O91080
O91080 (136 more...) |
HIV-1 retropepsin.
[EC: 3.4.23.16]
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
|
98 |
O12158
O12158
O41798
O41798
O89290
O89290
O89940
O89940
O91080
O91080 (88 more...) |
Ribonuclease H.
[EC: 3.1.26.4]
Endonucleolytic cleavage to 5'-phosphomonoester.
|
46 |
P03362
P03362
P03363
P03363
P03364
P03364
P03365
P03365
P04025
P04025 (36 more...) |
HIV-2 retropepsin.
[EC: 3.4.23.47]
Endopeptidase for which the P1 residue is preferably hydrophobic.
|
24 |
P04584
P04584
P05962
P05962
P12451
P12451
P15833
P15833
P17757
P17757 (14 more...) |
DUTP diphosphatase.
[EC: 3.6.1.23]
dUTP + H(2)O = dUMP + diphosphate.
|
18 |
P03370
P03370
P16088
P16088
P16901
P16901
P19028
P19028
P23426
P23426 (8 more...) |