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CATH Superfamily 3.30.420.10

Ribonuclease H-like superfamily/Ribonuclease H

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 45932: Argonaute 2, isoform E

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Argonaute-2. [EC: 3.1.26.n2]
Endonucleolytic cleavage to 5'-phosphomonoester.
  • The enzyme, isolated from animals, is required for RNA-mediated gene silencing (RNAi).
 134 A0A060XJA5 A0A060XJA5 A0A068FJ89 A0A068FJ89 A0A087XI25 A0A087XI25 A0A0D9RB41 A0A0D9RB41 A0A151P872 A0A151P872
(124 more...)
Diacylglycerol kinase (ATP). [EC: 2.7.1.107]
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
  • Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol.
  • Activity is stimulated by certain phospholipids.
  • In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger.
  • cf. EC 2.7.1.174.
 6 A0A0V0SDL5 A0A0V0SDL5 A0A0V0SDS7 A0A0V0SDS7 A0A0V0SDY3 A0A0V0SDY3
Calcium-transporting ATPase. [EC: 3.6.3.8]
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum and in Saccharomyces cerevisiae.
  • The first and third transport one ion per ATP hydrolyzed, whereas the second transports two ions.
  • Formerly EC 3.6.1.38.
 2 A0A0B7NMQ4 A0A0B7NMQ4
Ubiquitinyl hydrolase 1. [EC: 3.4.19.12]
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
  • Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides.
  • Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals.
  • Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde).
  • Belongs to peptidase family C12.
 2 A0A1B0CL75 A0A1B0CL75
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