The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Ribonuclease H-like superfamily/Ribonuclease H
".
FunFam 45852: ERI1 exoribonuclease 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
|
1 | Q08I43 (/IMP) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
1 | Q10905 (/IDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | O43414 (/IDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q8C460 (/ISO) |
|
Endodeoxyribonuclease activity GO:0004520
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
|
1 | Q10905 (/IDA) |
|
Deoxyribonuclease activity GO:0004536
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
|
1 | Q10905 (/IDA) |
|
Ribonuclease activity GO:0004540
Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
|
1 | Q10905 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q8C460 (/IPI) |
|
3'-5' exonuclease activity GO:0008408
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
|
1 | Q10905 (/IDA) |
|
3'-5' exonuclease activity GO:0008408
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
|
1 | Q10905 (/ISS) |
|
Double-stranded RNA-specific ribonuclease activity GO:0032296
Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules.
|
1 | Q08I43 (/IDA) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000467
Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.
|
1 | Q08I43 (/IMP) |
|
DNA catabolic process, endonucleolytic GO:0000737
The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
|
1 | Q10905 (/IDA) |
|
DNA catabolic process, exonucleolytic GO:0000738
The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
|
1 | Q10905 (/IDA) |
|
Apoptotic DNA fragmentation GO:0006309
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
|
1 | Q10905 (/IDA) |
|
Apoptotic DNA fragmentation GO:0006309
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
|
1 | Q10905 (/IGI) |
|
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
|
1 | Q10905 (/IDA) |
|
Negative regulation of chromatin silencing by small RNA GO:0060906
Any process that decreases the frequency, rate or extent of chromatin silencing by small RNA. Chromatin silencing by small RNA is the repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region.
|
1 | Q08I43 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q08I43 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q08I43 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8C460 (/TAS) |