The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Ribonuclease H-like superfamily/Ribonuclease H
".
FunFam 45751: Pol polyprotein
There are 5 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
RNA-directed DNA polymerase.
[EC: 2.7.7.49]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
12 |
P03370
P03371
P11204
P16901
P19560
P23426
P23427
P32542
P33459
P35956 (2 more...) |
Retroviral ribonuclease H.
[EC: 3.1.26.13]
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
|
12 |
P03370
P03371
P11204
P16901
P19560
P23426
P23427
P32542
P33459
P35956 (2 more...) |
Exoribonuclease H.
[EC: 3.1.13.2]
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
|
12 |
P03370
P03371
P11204
P16901
P19560
P23426
P23427
P32542
P33459
P35956 (2 more...) |
DUTP diphosphatase.
[EC: 3.6.1.23]
dUTP + H(2)O = dUMP + diphosphate.
|
6 | P03370 P16901 P23426 P23427 P35956 Q1W0S4 |
DNA-directed DNA polymerase.
[EC: 2.7.7.7]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
2 | P19560 Q82851 |