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CATH Superfamily 3.30.420.10

Ribonuclease H-like superfamily/Ribonuclease H

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 45004: Exonuclease 3'-5' domain-containing protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
 2 Q6NRD5 (/ISS) Q8NHP7 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
 2 Q6NRD5 (/ISS) Q8NHP7 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 1 Q8NHP7 (/IPI)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Gene silencing by RNA GO:0031047
Any process in which RNA molecules inactivate expression of target genes.
 2 Q6NRD5 (/ISS) Q8NHP7 (/ISS)
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
 2 Q6NRD5 (/ISS) Q8NHP7 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
 2 Q6NRD5 (/ISS) Q8NHP7 (/ISS)
PET complex GO:1990923
A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs
 2 Q6NRD5 (/ISS) Q8NHP7 (/ISS)