The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2229: Piwi-like protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoribonuclease activity GO:0004521
Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
4 A2CEI6 (/ISS) A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 A2CEI6 (/IPI) A8KBF3 (/IPI) Q8CDG1 (/IPI)
PiRNA binding GO:0034584
Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
3 A2CEI6 (/IDA) Q8CDG1 (/IDA) Q8TC59 (/IDA)
PiRNA binding GO:0034584
Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
3 A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q8CDG1 (/IDA)
Endoribonuclease activity GO:0004521
Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
1 Q8CDG1 (/IMP)
PiRNA binding GO:0034584
Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
1 Q8CDG1 (/ISO)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA 5'-end processing GO:0000966
Any process involved in forming the mature 5' end of an RNA molecule.
4 A2CEI6 (/ISS) A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
4 A2CEI6 (/ISS) A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
Negative regulation of transposition GO:0010529
Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites.
4 A2CEI6 (/ISS) A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
Gene silencing by RNA GO:0031047
Any process in which RNA molecules inactivate expression of target genes.
4 A2CEI6 (/ISS) A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
DNA methylation involved in gamete generation GO:0043046
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
4 A2CEI6 (/ISS) A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
3 A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
3 A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
Gamete generation GO:0007276
The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
2 A6P7L8 (/ISS) A8KBF3 (/ISS)
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
2 A2CEI6 (/IMP) Q8CDG1 (/IMP)
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
2 A2CEI6 (/IDA) Q8CDG1 (/IDA)
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
2 A6P7L8 (/ISS) A8KBF3 (/ISS)
RNA 5'-end processing GO:0000966
Any process involved in forming the mature 5' end of an RNA molecule.
1 Q8CDG1 (/IDA)
Gamete generation GO:0007276
The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
1 A2CEI6 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q8CDG1 (/IMP)
Negative regulation of transposition GO:0010529
Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites.
1 Q8CDG1 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 A2CEI6 (/IGI)
Negative regulation of SMAD protein complex assembly GO:0010991
Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins.
1 A2CEI6 (/IPI)
Gene silencing by RNA GO:0031047
Any process in which RNA molecules inactivate expression of target genes.
1 Q8CDG1 (/IMP)
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
1 Q8CDG1 (/IMP)
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
1 Q8CDG1 (/TAS)
DNA methylation involved in gamete generation GO:0043046
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
1 Q8CDG1 (/IMP)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
1 Q8CDG1 (/IMP)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
1 Q8TC59 (/ISS)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
1 Q8CDG1 (/IEP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
1 Q8TC59 (/ISS)
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
1 A2CEI6 (/IMP)
Positive regulation of meiosis I GO:0060903
Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.
1 Q8CDG1 (/IMP)
Positive regulation of histone H3-K14 acetylation GO:0071442
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone.
1 Q8CDG1 (/IMP)
Positive regulation of histone H3-K9 acetylation GO:2000617
Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation.
1 Q8CDG1 (/IDA)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
4 A2CEI6 (/ISS) A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
Pi-body GO:0071546
A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes.
4 A2CEI6 (/ISS) A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
PET complex GO:1990923
A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs
4 A2CEI6 (/ISS) A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 A6P7L8 (/ISS) A8KBF3 (/ISS) Q8TC59 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 A2CEI6 (/IDA) Q8CDG1 (/IDA)
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
2 A2CEI6 (/IDA) Q8CDG1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 A2CEI6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8CDG1 (/TAS)
Perinucleolar chromocenter GO:0010370
A chromocenter adjacent to the nucleolus.
1 Q8CDG1 (/IDA)
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
1 Q8CDG1 (/IDA)
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
1 Q8TC59 (/ISS)
Pi-body GO:0071546
A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes.
1 Q8CDG1 (/IDA)
Dense body GO:0097433
An electron dense body which may contain granules.
1 Q8CDG1 (/IDA)
PET complex GO:1990923
A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs
1 Q8CDG1 (/IDA)