The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Arf GTPase activating protein

Structural domains comprising this superfamily share the structure of the ARF1-directed GTPase-activating protein, the cycle control GTPase activating protein (GAP) GCS1 which is important for the regulation of the ADP ribosylation factor ARF, a member of the Ras superfamily of GTP-binding proteins PMID:9446556. The GTP-bound form of ARF is required to maintain normal Golgi morphology, it participates in recruitment of coat proteins which are required for budding and fission of membranes. Hydrolysis of ARF-GTP promotes uncoating and fusion with an acceptor compartment. Before the fusion with an acceptor compartment the membrane must be uncoated. This ARF-GAP domain display no obvious similarity to other GAP proteins.

GO Diversity

Unique GO annotations
237 Unique GO terms

EC Diversity

Unique EC annotations
17 Unique EC terms

Species Diversity

Unique species annotations
1554 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 32
Domain clusters (>95% seq id): 11
Domain clusters (>35% seq id): 6
Unique PDBs: 19
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 17
Unique GO: 237
Unique Species: 1554