The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Cytoplasmic polyadenylation element-binding protein, ZZ domain

Structural domains comprising this superfamily share the structure of the zinc binding domain (ZZ) of the cytoplasmic polyadenylation element-binding proteins (CPEBs), RNA-binding proteins that are essential regulators of post-transcriptional gene expression. CPEB regulates protein expression by inhibiting polyadenylation of selected mRNA transcripts, which prevents binding of the ribosome for protein synthesis PMID:23500490. Its ZZ domain has shown to be an interaction domain and to have a dual function, as it contributes to increasing the affinity of the RNA recognition motifs (RRMs) for the CPEs and to promotes interactions with other protein factors in the translational repression/activation complexes assembled by CPEBs PMID:24990967.

GO Diversity

Unique GO annotations
117 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
689 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 2
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 1
Unique GO: 117
Unique Species: 689