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CATH Superfamily 3.30.40.10

Zinc/RING finger domain, C3HC4 (zinc finger)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Zinc/RING finger domain, C3HC4 (zinc finger)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 60312: E3 ubiquitin-protein ligase RNF5

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
RING-type E3 ubiquitin transferase. [EC: 2.3.2.27]
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
  • The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein.
  • The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC 2.3.2.26).
  • RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies.
  • Formerly EC 6.3.2.19 and EC 6.3.2.21.
 33 A0A024R1F5 A0A024RCQ4 A0A091MWD6 A0A178UX84 A0A178V4H3 A0A1A6HGD2 B2KIG3 D2H206 F1PCX5 F2Z4Y3
(23 more...)
Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45. [EC: 6.3.2.19]
    		25 A0A0B2P5L3 A0A0B2PA12 A0A0B2PDJ6 A0A0B2PGL2 A0A0B2PHT6 A0A0B2PQQ5 A0A0B2QLL5 A0A0B2R1L9 A0A0B2RI33 A0A0B2RSD4
    (15 more...)
    2-alkenal reductase (NAD(P)(+)). [EC: 1.3.1.74]
    A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
    • Highly specific for 4-hydroxynon-2-enal and non-2-enal.
    • Alk-2-enals of shorter chain have lower affinities.
    • Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one.
    • Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid.
    • Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
    		 1 B7QP09
    Microtubule-severing ATPase. [EC: 3.6.4.3]
    ATP + H(2)O = ADP + phosphate.
    • Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
    		 1 A0A139AJ06