The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 59787: E3 ubiquitin-protein ligase Arkadia
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | E9QAU8 (/IPI) Q6ZNA4 (/IPI) Q99ML9 (/IPI) |
|
SUMO polymer binding GO:0032184
Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO.
|
2 | Q5R476 (/ISS) Q99ML9 (/ISS) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
2 | A0A0G2JVQ0 (/IPI) D4A9T1 (/IPI) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
2 | Q6ZNA4 (/IMP) Q99ML9 (/IMP) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q99ML9 (/TAS) |
|
SUMO polymer binding GO:0032184
Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO.
|
1 | Q6ZNA4 (/IDA) |
|
SUMO polymer binding GO:0032184
Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO.
|
1 | Q99ML9 (/ISO) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | E9QAU8 (/IDA) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q99ML9 (/ISO) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q6ZNA4 (/TAS) |
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Prechordal plate formation GO:0021501
The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.
|
6 | F1QWE1 (/IMP) N0A274 (/IMP) R4KWC4 (/IMP) R4L154 (/IMP) R4L5N0 (/IMP) R4L6W8 (/IMP) |
|
Epiboly involved in gastrulation with mouth forming second GO:0055113
The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.
|
6 | F1QWE1 (/IMP) N0A274 (/IMP) R4KWC4 (/IMP) R4L154 (/IMP) R4L5N0 (/IMP) R4L6W8 (/IMP) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
2 | E9QAU8 (/IDA) Q99ML9 (/IDA) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
1 | Q99ML9 (/IGI) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
1 | Q99ML9 (/IMP) |
|
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
|
1 | Q99ML9 (/IMP) |
|
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
|
1 | E9QAU8 (/IMP) |
|
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | E9QAU8 (/IMP) |
|
Multicellular organism aging GO:0010259
An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).
|
1 | E9QAU8 (/IMP) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | Q6ZNA4 (/IMP) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | Q99ML9 (/ISO) |
|
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
1 | E9QAU8 (/IDA) |
|
Positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511
Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
|
1 | Q99ML9 (/IDA) |
|
Positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511
Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
|
1 | Q99ML9 (/IMP) |
|
Positive regulation of BMP signaling pathway GO:0030513
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
|
1 | E9QAU8 (/IMP) |
|
Ubiquitin-dependent SMAD protein catabolic process GO:0030579
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
|
1 | Q99ML9 (/IDA) |
|
Ubiquitin-dependent SMAD protein catabolic process GO:0030579
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
|
1 | Q99ML9 (/IMP) |
|
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | Q99ML9 (/IDA) |
|
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | Q99ML9 (/IMP) |
|
Forelimb morphogenesis GO:0035136
The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
|
1 | E9QAU8 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q99ML9 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q6ZNA4 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q99ML9 (/ISO) |
|
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q6ZNA4 (/TAS) |
|
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
|
1 | E9QAU8 (/IGI) |
|
Innervation GO:0060384
The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue.
|
1 | E9QAU8 (/IMP) |
|
Muscle structure development GO:0061061
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
|
1 | E9QAU8 (/IMP) |
|
Global genome nucleotide-excision repair GO:0070911
The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome.
|
1 | Q6ZNA4 (/TAS) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | A0A024R5T5 (/IDA) E9QAU8 (/IDA) Q6ZNA4 (/IDA) Q99ML9 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q6ZNA4 (/TAS) Q99ML9 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | A0A024R5T5 (/IDA) Q6ZNA4 (/IDA) |
|
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
2 | E9QAU8 (/IDA) Q99ML9 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q99ML9 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q99ML9 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q99ML9 (/ISO) |