The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 33899: E3 ubiquitin-protein ligase RNF4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 27 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | O88846 (/IPI) P78317 (/IPI) Q9QZS2 (/IPI) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | P78317 (/ISS) Q9QZS2 (/ISS) |
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
2 | P78317 (/ISS) Q9QZS2 (/ISS) |
Nucleosome binding GO:0031491
Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
|
2 | P78317 (/ISS) Q9QZS2 (/ISS) |
SUMO polymer binding GO:0032184
Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO.
|
2 | P78317 (/ISS) Q9QZS2 (/ISS) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | O88846 (/IDA) |
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
|
1 | P78317 (/TAS) |
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
|
1 | P78317 (/NAS) |
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | O88846 (/IDA) |
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | O88846 (/IMP) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
|
1 | Q9QZS2 (/IPI) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | O88846 (/IDA) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | P78317 (/TAS) |
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
|
1 | O88846 (/IDA) |
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
|
1 | O88846 (/IPI) |
Nucleosome binding GO:0031491
Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
|
1 | O88846 (/IDA) |
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
|
1 | O88846 (/IPI) |
SUMO polymer binding GO:0032184
Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO.
|
1 | O88846 (/IDA) |
SUMO polymer binding GO:0032184
Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO.
|
1 | O88846 (/IPI) |
Progesterone receptor binding GO:0033142
Interacting selectively and non-covalently with a progesterone receptor.
|
1 | O88846 (/IPI) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P78317 (/IPI) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q9QZS2 (/ISO) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | O88846 (/IDA) |
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
1 | O88846 (/IPI) |
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
1 | P78317 (/NAS) |
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | O88846 (/IDA) |
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | P78317 (/TAS) |
There are 39 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | O88846 (/IDA) P78317 (/IDA) Q9QZS2 (/IDA) |
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
2 | O88846 (/ISS) Q9QZS2 (/ISS) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P78317 (/ISS) Q9QZS2 (/ISS) |
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | O88846 (/ISS) Q9QZS2 (/ISS) |
Response to arsenic-containing substance GO:0046685
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
|
2 | O88846 (/IDA) P78317 (/IDA) |
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
2 | P78317 (/ISS) Q9QZS2 (/ISS) |
Protein K63-linked ubiquitination GO:0070534
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
|
2 | P78317 (/ISS) Q9QZS2 (/ISS) |
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
|
2 | P78317 (/ISS) Q9QZS2 (/ISS) |
Protein K11-linked ubiquitination GO:0070979
A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.
|
2 | P78317 (/ISS) Q9QZS2 (/ISS) |
Protein K6-linked ubiquitination GO:0085020
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair.
|
2 | P78317 (/ISS) Q9QZS2 (/ISS) |
Regulation of spindle assembly GO:0090169
Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
|
2 | O88846 (/ISS) Q9QZS2 (/ISS) |
Regulation of kinetochore assembly GO:0090234
Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
2 | O88846 (/ISS) Q9QZS2 (/ISS) |
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | O88846 (/IEP) |
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
|
1 | O88846 (/IEP) |
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | O88846 (/IMP) |
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
|
1 | P78317 (/NAS) |
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
1 | O88846 (/IEP) |
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | P78317 (/IMP) |
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | Q9QZS2 (/ISO) |
Response to human chorionic gonadotropin GO:0044752
Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus.
|
1 | O88846 (/IEP) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | O88846 (/IDA) |
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q9QZS2 (/ISO) |
Response to arsenic-containing substance GO:0046685
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
|
1 | Q9QZS2 (/ISO) |
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | O88846 (/IDA) |
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | O88846 (/IMP) |
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
|
1 | O88846 (/IMP) |
Protein K63-linked ubiquitination GO:0070534
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
|
1 | O88846 (/IDA) |
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
|
1 | O88846 (/IDA) |
Protein K11-linked ubiquitination GO:0070979
A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.
|
1 | O88846 (/IDA) |
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
|
1 | O88846 (/IEP) |
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | O88846 (/IEP) |
Cellular response to testosterone stimulus GO:0071394
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
|
1 | O88846 (/IDA) |
Cellular response to gamma radiation GO:0071480
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
|
1 | O88846 (/IMP) |
Cellular response to hydroxyurea GO:0072711
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.
|
1 | O88846 (/IMP) |
Protein K6-linked ubiquitination GO:0085020
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair.
|
1 | O88846 (/IDA) |
Regulation of spindle assembly GO:0090169
Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
|
1 | P78317 (/IMP) |
Regulation of spindle assembly GO:0090169
Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
|
1 | Q9QZS2 (/ISO) |
Regulation of kinetochore assembly GO:0090234
Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
1 | P78317 (/IMP) |
Regulation of kinetochore assembly GO:0090234
Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
1 | Q9QZS2 (/ISO) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O88846 (/IDA) P78317 (/IDA) Q9QZS2 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P78317 (/IDA) Q9QZS2 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O88846 (/ISS) Q9QZS2 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9QZS2 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9QZS2 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | O88846 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P78317 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9QZS2 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O88846 (/IDA) |