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CATH Superfamily 3.30.390.30

FAD/NAD-linked reductase, C-terminal dimerisation domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 627: Mercuric reductase (Hg(II) reductase)

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mercury(II) reductase. [EC: 1.16.1.1]
Hg + NADP(+) + H(+) = Hg(2+) + NADPH.
    		 773 A0A009KF76 A0A016XLT6 A0A023VHJ6 A0A024EL52 A0A024ELH6 A0A024HVQ2 A0A029KY55 A0A031MCB3 A0A038GUZ5 A0A059IR92
    (763 more...)
    Dihydrolipoyl dehydrogenase. [EC: 1.8.1.4]
    Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
    • A component of the multienzyme 2-oxo-acid dehydrogenase complexes.
    • In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups.
    • It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes.
    • Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts, together with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.
    • It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate.
    • Was first shown to catalyze the oxidation of NADH by methylene blue; this activity was called diaphorase.
    • The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
    • Formerly EC 1.6.4.3.
    		 6 A0A0A6S016 A0A0W0YZZ2 A0A1L5JN69 G9AYH0 Q54465 Q79RJ0