View in Gene3D

CATH Superfamily 3.30.390.30

FAD/NAD-linked reductase, C-terminal dimerisation domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2312: Pyridine nucleotide-disulfide oxidoreductase famil...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mercury(II) reductase. [EC: 1.16.1.1]
Hg + NADP(+) + H(+) = Hg(2+) + NADPH.
    		 131 A0A023YSI8 A0A024L6A0 A0A025BVM8 A0A027TBE4 A0A028ALF3 A0A028E6Y1 A0A029L2H3 A0A066PAB0 A0A066QMP8 A0A070DE50
    (121 more...)
    Dihydrolipoyl dehydrogenase. [EC: 1.8.1.4]
    Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
    • A component of the multienzyme 2-oxo-acid dehydrogenase complexes.
    • In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups.
    • It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes.
    • Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts, together with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.
    • It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate.
    • Was first shown to catalyze the oxidation of NADH by methylene blue; this activity was called diaphorase.
    • The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
    • Formerly EC 1.6.4.3.
    		 32 A0A023YSI8 A0A025BVM8 A0A085GBD7 A0A085GMT9 A0A0A1RJ52 A0A0D8WJM5 A0A0E2TMA6 A0A0F3U6X9 A0A0H7WY05 A0A125XKT5
    (22 more...)
    NAD(P)(+) transhydrogenase (Si-specific). [EC: 1.6.1.1]
    NADPH + NAD(+) = NADP(+) + NADH.
    • Si-specific with respect to both NAD(+) and NADP(+).
    • Also acts with deamino coenzymes.
    		 18 A0A024L6A0 A0A070SN23 A0A070UJ47 A0A074IL36 A0A0E0TV55 A0A0E1LY60 A0A0H3X1Y6 A0A0M7MSS8 A0A0P7ZP61 A0A125X7C1
    (8 more...)