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CATH Superfamily 3.30.360.10

Dihydrodipicolinate Reductase; domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Dihydrodipicolinate Reductase; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24436: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
D-xylose 1-dehydrogenase (NADP(+)). [EC: 1.1.1.179]
D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH.
  • Also acts, more slowly, on L-arabinose and D-ribose.
 32 A0A1L8FNG7 A0A1L8FNG7 H9EXM3 H9EXM3 L8IJA1 L8IJA1 Q148L6 Q148L6 Q5R5J5 Q5R5J5
(22 more...)
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. [EC: 1.3.1.20]
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
    		 30 A0A1L8FNG7 A0A1L8FNG7 H9EXM3 H9EXM3 L8IJA1 L8IJA1 Q148L6 Q148L6 Q5R5J5 Q5R5J5
    (20 more...)
    2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase. [EC: 1.1.1.312]
    4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo- 2H-pyran-4,6-dicarboxylate + NADPH.
    • The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD(+) can replace NADP(+), but with lower affinity.
    • The enzyme was initially believed to act on 4-carboxy-2-hydroxy- cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy- cis,cis-muconate.
    • However, later studies showed that the substrate is the hemiacetal form, and the product is 2-oxo-2H-pyran-4,6-dicarboxylate.
    • Formerly EC 1.2.1.45.
    		 10 A0A0K6KE74 A0A0K6KE74 A0A0K6KEV1 A0A0K6KEV1 A0A0K6LBR7 A0A0K6LBR7 A0A0K6M8A6 A0A0K6M8A6 A0A0T8PU41 A0A0T8PU41
    Glucose-fructose oxidoreductase. [EC: 1.1.99.28]
    D-glucose + D-fructose = D-gluconolactone + D-glucitol.
    • D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities.
    • The ketose substrate must be in the open-chain form.
    • The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form.
    • Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates.
    • The enzyme from Zymomonas mobilis contains tightly bound NADP(+).
    		 4 A0A0K6KE74 A0A0K6KE74 A0A0T8PU41 A0A0T8PU41