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CATH Superfamily 3.30.360.10

Dihydrodipicolinate Reductase; domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Dihydrodipicolinate Reductase; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24281: Bifunctional aspartokinase/homoserine dehydrogenas...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Homoserine dehydrogenase. [EC: 1.1.1.3]
L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H.
  • The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+).
  • The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 2.7.2.4.
 3776 A0A010S558 A0A010S558 A0A011LZF9 A0A011LZF9 A0A014M226 A0A014M226 A0A015L4W4 A0A015L4W4 A0A017IQQ4 A0A017IQQ4
(3766 more...)
Aspartate kinase. [EC: 2.7.2.4]
ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
  • The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3.
  • This is also the case for two of the four isoenzymes in Arabidopsis thaliana.
  • The equilibrium constant strongly favors the reaction from right to left, i.e. the non-physiological direction of reaction.
 2094 A0A010Q7M7 A0A010Q7M7 A0A011LZF9 A0A011LZF9 A0A014M226 A0A014M226 A0A022PJD9 A0A022PJD9 A0A023V6Q9 A0A023V6Q9
(2084 more...)
L-arabinitol 2-dehydrogenase. [EC: 1.1.1.13]
L-arabinitol + NAD(+) = L-ribulose + NADH.
    		 76 A0A0B6FTL1 A0A0B6FTL1 A0A0E1NQJ6 A0A0E1NQJ6 A0A0E8XK29 A0A0E8XK29 A0A0F6ZMS1 A0A0F6ZMS1 A0A0H2YFP4 A0A0H2YFP4
    (66 more...)
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase. [EC: 2.5.1.7]
    Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP- N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.
      		 2 A9E3R4 A9E3R4
      Mevaldate reductase. [EC: 1.1.1.32]
      (R)-mevalonate + NAD(+) = mevaldate + NADH.
        		 2 B3H092 B3H092