The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
TATA-Binding Protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1233: TATA box binding protein-related factor 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Core promoter binding GO:0001047
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly GO:0001075
Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter.
4 M9PHD8 (/IC) Q07DP5 (/IC) Q8T052 (/IC) Q9XZD9 (/IC)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
4 M9PHD8 (/TAS) Q07DP5 (/TAS) Q8T052 (/TAS) Q9XZD9 (/TAS)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 M9PHD8 (/IMP) Q07DP5 (/IMP) Q8T052 (/IMP) Q9XZD9 (/IMP)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
4 M9PHD8 (/TAS) Q07DP5 (/TAS) Q8T052 (/TAS) Q9XZD9 (/TAS)
Salivary gland cell autophagic cell death GO:0035071
The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis.
4 M9PHD8 (/IMP) Q07DP5 (/IMP) Q8T052 (/IMP) Q9XZD9 (/IMP)
Response to ecdysone GO:0035075
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus.
4 M9PHD8 (/IMP) Q07DP5 (/IMP) Q8T052 (/IMP) Q9XZD9 (/IMP)
Pupal development GO:0035209
The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis.
4 M9PHD8 (/IMP) Q07DP5 (/IMP) Q8T052 (/IMP) Q9XZD9 (/IMP)
Spiracle morphogenesis, open tracheal system GO:0035277
The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk.
4 M9PHD8 (/IMP) Q07DP5 (/IMP) Q8T052 (/IMP) Q9XZD9 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
4 M9PHD8 (/IMP) Q07DP5 (/IMP) Q8T052 (/IMP) Q9XZD9 (/IMP)
Positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter GO:0060963
Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter GO:0060963
Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter.
4 M9PHD8 (/IMP) Q07DP5 (/IMP) Q8T052 (/IMP) Q9XZD9 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Male germ cell nucleus GO:0001673
The nucleus of a male germ cell, a reproductive cell in males.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Female germ cell nucleus GO:0001674
The nucleus of the female germ cell, a reproductive cell in females.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)
Transcription factor TFIID complex GO:0005669
A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
4 M9PHD8 (/ISS) Q07DP5 (/ISS) Q8T052 (/ISS) Q9XZD9 (/ISS)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
4 M9PHD8 (/IDA) Q07DP5 (/IDA) Q8T052 (/IDA) Q9XZD9 (/IDA)