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CATH Superfamily 3.30.230.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28418: Similar to mevalonate kinase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mevalonate kinase. [EC: 2.7.1.36]
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.
  • CTP, GTP and UTP can also act as donors.
 1091 A0A010RSL8 A0A014NAH7 A0A014NAH7 A0A014NCB5 A0A015L7P9 A0A022R4B8 A0A022VVS8 A0A022XLA8 A0A023ESL4 A0A024SCE4
(1081 more...)
Cystathionine beta-lyase. [EC: 4.4.1.8]
L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate.
  • The enzyme cleaves a carbon-sulfur bond, releasing L-homocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds.
  • Possibly identical, in Saccharomyces cerevisiae, with EC 4.4.1.6.
 3 A0A0B7FWR5 A0A0L6U6B1 M5C1R1
Hydroxymethylglutaryl-CoA synthase. [EC: 2.3.3.10]
Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
  • Formerly EC 4.1.3.5.
 2 A0A0K2DUQ8 A0A0K2L175
3-hydroxyisobutyrate dehydrogenase. [EC: 1.1.1.31]
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.
    		 1 A0A0K0EQ95
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