The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Metalloproteases ("zincins"), catalytic domain
".
FunFam 4993: Mitochondrial inner membrane metallopeptidase Oma1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
|
3 | D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) |
|
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
|
1 | Q9D8H7 (/ISO) |
|
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
1 | Q487G9 (/ISS) |
There are 19 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrial protein processing GO:0034982
The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.
|
4 | D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) Q9D8H7 (/ISS) |
|
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
|
3 | D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) |
|
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
|
3 | D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) |
|
Misfolded or incompletely synthesized protein catabolic process GO:0006515
The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.
|
3 | D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) |
|
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
|
3 | D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) |
|
Response to stress GO:0006950
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
3 | D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) |
|
Negative regulation of mitochondrial fusion GO:0010637
Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.
|
3 | D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) |
|
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
|
3 | D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) |
|
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
|
1 | Q9D8H7 (/ISO) |
|
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
|
1 | Q9D8H7 (/ISO) |
|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
1 | Q487G9 (/ISS) |
|
Misfolded or incompletely synthesized protein catabolic process GO:0006515
The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.
|
1 | Q9D8H7 (/ISO) |
|
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
|
1 | Q9D8H7 (/ISO) |
|
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
|
1 | Q9D8H7 (/IGI) |
|
Negative regulation of mitochondrial fusion GO:0010637
Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.
|
1 | Q9D8H7 (/ISO) |
|
Mitochondrial protein processing GO:0034982
The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.
|
1 | Q9D8H7 (/IMP) |
|
Mitochondrial protein processing GO:0034982
The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.
|
1 | Q9D8H7 (/ISO) |
|
Cristae formation GO:0042407
The assembly of cristae, the inwards folds of the inner mitochondrial membrane.
|
1 | Q9D8H7 (/IGI) |
|
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
|
1 | Q9D8H7 (/ISO) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
|
3 | D3ZS74 (/ISS) E9QBI7 (/ISS) Q3SZN3 (/ISS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9D8H7 (/IDA) |
|
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
|
1 | Q9D8H7 (/ISO) |