The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Phosphorylase Kinase; domain 1
".
FunFam 65104: Eukaryotic translation initiation factor 2-alpha k...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | Q9P2K8 (/ISS) |
|
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
|
1 | Q9P2K8 (/IMP) |
There are 29 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Regulation of translational initiation by eIF2 alpha phosphorylation GO:0010998
Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Viral translation GO:0019081
A process by which viral mRNA is translated into viral protein, using the host cellular machinery.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Negative regulation of CREB transcription factor activity GO:0032792
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Negative regulation by host of viral genome replication GO:0044828
A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Negative regulation of translational initiation GO:0045947
Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Regulation of eIF2 alpha phosphorylation by amino acid starvation GO:0060733
Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Positive regulation of translational initiation in response to starvation GO:0071264
Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
Positive regulation of long-term synaptic potentiation GO:1900273
Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.
|
2 | D4A7V9 (/ISS) Q9P2K8 (/ISS) |
|
T cell activation involved in immune response GO:0002286
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
|
1 | Q9P2K8 (/ISS) |
|
Positive regulation of adaptive immune response GO:0002821
Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
|
1 | Q9P2K8 (/ISS) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
1 | Q9P2K8 (/ISS) |
|
Regulation of translational initiation by eIF2 alpha phosphorylation GO:0010998
Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
|
1 | Q9P2K8 (/IMP) |
|
Negative regulation of translational initiation in response to stress GO:0032057
Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.
|
1 | Q9P2K8 (/ISS) |
|
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
|
1 | Q9P2K8 (/IMP) |
|
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
|
1 | Q9P2K8 (/ISS) |
|
Cellular response to UV GO:0034644
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
|
1 | Q9P2K8 (/ISS) |
|
EiF2alpha phosphorylation in response to endoplasmic reticulum stress GO:0036492
The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.
|
1 | Q9P2K8 (/IMP) |
|
Induction by virus of host autophagy GO:0039520
Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.
|
1 | Q9P2K8 (/ISS) |
|
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
|
1 | Q9P2K8 (/ISS) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
1 | Q9P2K8 (/ISS) |
|
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
|
1 | Q9P2K8 (/ISS) |
|
Regulation of eIF2 alpha phosphorylation by amino acid starvation GO:0060733
Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation.
|
1 | Q9P2K8 (/IMP) |
|
Cellular response to cold GO:0070417
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
|
1 | Q9P2K8 (/IMP) |
|
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q9P2K8 (/ISS) |
|
Cellular response to leucine starvation GO:1990253
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine.
|
1 | Q9P2K8 (/ISS) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Polysome GO:0005844
A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.
|
1 | Q9P2K8 (/ISS) |
|
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
|
1 | Q9P2K8 (/ISS) |
