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CATH Superfamily 3.30.200.20

Phosphorylase Kinase; domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6109: Serine/threonine-protein kinase TBK1

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 10 A0A1L8GYK0 A0A1L8GYK0 A1L361 A1L361 Q6DFJ6 Q6DFJ6 Q9UHD2 Q9UHD2 Q9WUN2 Q9WUN2
Dual-specificity kinase. [EC: 2.7.12.1]
ATP + a protein = ADP + a phosphoprotein.
  • This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
  • Formerly EC 2.7.1.37.
 6 A0A0A8LCK5 A0A0A8LCK5 Q75CE9 Q75CE9 R9XFY8 R9XFY8
I-kappa-B kinase. [EC: 2.7.11.10]
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
  • Phosphorylates I-kappa-B proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway.
  • Subsequent degradation of the I-kappa-B complex (IKK) activates NF-kappa-B, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis.
  • If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
  • Formerly EC 2.7.1.37.
 4 E0VQV7 E0VQV7 Q9V3Y8 Q9V3Y8
Mitogen-activated protein kinase kinase kinase. [EC: 2.7.11.25]
ATP + a protein = ADP + a phosphoprotein.
  • This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation.
  • Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras.
  • While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
 2 B7Q1Z3 B7Q1Z3
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