The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Phosphorylase Kinase; domain 1
".
FunFam 2531: Protein kinase C epsilon type
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 44 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
P09215 (/IPI)
P09216 (/IPI)
P13677 (/IPI)
P16054 (/IPI)
P23298 (/IPI)
P28867 (/IPI)
Q02111 (/IPI)
Q02156 (/IPI)
Q04759 (/IPI)
Q05655 (/IPI)
(1 more) |
|
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
|
7 | G8JY36 (/IDA) H9G2Y7 (/IDA) P28867 (/IDA) P34885 (/IDA) P90980 (/IDA) Q02111 (/IDA) Q02156 (/IDA) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
6 | P05130 (/NAS) P13677 (/NAS) P13678 (/NAS) P34885 (/NAS) P83099 (/NAS) Q04759 (/NAS) |
|
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
|
6 | P05130 (/ISS) P09215 (/ISS) P13677 (/ISS) P13678 (/ISS) Q05655 (/ISS) Q5PU49 (/ISS) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
4 | P05130 (/IDA) P16054 (/IDA) Q02156 (/IDA) Q05655 (/IDA) |
|
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
|
3 | P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
3 | P16054 (/ISO) P28867 (/ISO) Q02111 (/ISO) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
3 | Q04759 (/TAS) Q05655 (/TAS) Q9WTQ0 (/TAS) |
|
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
|
3 | P24723 (/TAS) Q02156 (/TAS) Q05655 (/TAS) |
|
Calcium-independent protein kinase C activity GO:0004699
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.
|
3 | P09215 (/IDA) P16054 (/IDA) Q64617 (/IDA) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
3 | P24723 (/IPI) Q02156 (/IPI) Q05655 (/IPI) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
3 | P16054 (/ISO) P23298 (/ISO) P28867 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
3 | P09215 (/IPI) P09216 (/IPI) Q05655 (/IPI) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | Q04759 (/EXP) Q05655 (/EXP) |
|
Calcium-dependent protein kinase C activity GO:0004698
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium.
|
2 | G8JY36 (/IDA) P90980 (/IDA) |
|
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
|
2 | P16054 (/ISO) P28867 (/ISO) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
2 | Q02156 (/IDA) Q05655 (/IDA) |
|
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
|
1 | P16054 (/IDA) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q05655 (/IDA) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | P28867 (/ISO) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q04759 (/TAS) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | P34722 (/IMP) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | Q5PU49 (/ISS) |
|
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
|
1 | P09216 (/IMP) |
|
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
|
1 | P16054 (/ISO) |
|
Calcium-independent protein kinase C activity GO:0004699
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.
|
1 | Q05655 (/EXP) |
|
Calcium-independent protein kinase C activity GO:0004699
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.
|
1 | P28867 (/ISO) |
|
Calcium-independent protein kinase C activity GO:0004699
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.
|
1 | Q05655 (/TAS) |
|
Signal transducer activity GO:0004871
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
1 | Q02156 (/TAS) |
|
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P09216 (/IPI) |
|
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
|
1 | Q05655 (/IDA) |
|
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
|
1 | Q02156 (/IMP) |
|
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
|
1 | P09216 (/IPI) |
|
Ral GTPase binding GO:0017160
Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases.
|
1 | P23298 (/IPI) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | Q05655 (/IPI) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | P28867 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | P28867 (/ISO) |
|
Receptor activator activity GO:0030546
The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.
|
1 | P16054 (/IDA) |
|
Mitogen-activated protein kinase kinase kinase binding GO:0031435
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
|
1 | P34722 (/IPI) |
|
Ethanol binding GO:0035276
Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH.
|
1 | P16054 (/IDA) |
|
Insulin receptor substrate binding GO:0043560
Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
|
1 | P28867 (/IPI) |
|
Insulin receptor substrate binding GO:0043560
Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
|
1 | Q05655 (/ISS) |
|
TIR domain binding GO:0070976
Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components.
|
1 | P09215 (/IPI) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
1 | P16054 (/IPI) |
There are 280 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
7 | P05130 (/IDA) P09215 (/IDA) P16054 (/IDA) Q02111 (/IDA) Q02156 (/IDA) Q05655 (/IDA) Q64617 (/IDA) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
5 | P05130 (/NAS) P13677 (/NAS) P13678 (/NAS) P34885 (/NAS) P83099 (/NAS) |
|
Negative regulation of glial cell apoptotic process GO:0034351
Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.
|
5 | P09215 (/ISS) P23298 (/ISS) P28867 (/ISS) Q5PU49 (/ISS) Q64617 (/ISS) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
4 | G8JY36 (/IDA) P90980 (/IDA) Q02156 (/IDA) Q05655 (/IDA) |
|
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
|
4 | P24723 (/TAS) Q02156 (/TAS) Q04759 (/TAS) Q05655 (/TAS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | P16054 (/ISO) P23298 (/ISO) P28867 (/ISO) |
|
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
3 | P24723 (/TAS) Q02156 (/TAS) Q05655 (/TAS) |
|
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
|
3 | P09216 (/ISS) P10830 (/ISS) P16054 (/ISS) |
|
Positive regulation of fibroblast migration GO:0010763
Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
|
3 | P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
3 | P09215 (/ISS) P28867 (/ISS) Q5PU49 (/ISS) |
|
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
|
3 | P09215 (/ISS) Q05655 (/ISS) Q5PU49 (/ISS) |
|
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
|
3 | P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) |
|
Lipopolysaccharide-mediated signaling pathway GO:0031663
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
|
3 | P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) |
|
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
|
3 | P09216 (/ISS) P10830 (/ISS) P16054 (/ISS) |
|
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
|
3 | P09215 (/ISS) P28867 (/ISS) Q5PU49 (/ISS) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
3 | P09215 (/IDA) P09216 (/IDA) Q9WTQ0 (/IDA) |
|
TRAM-dependent toll-like receptor 4 signaling pathway GO:0035669
Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
|
3 | P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) |
|
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
3 | P09215 (/ISS) Q05655 (/ISS) Q5PU49 (/ISS) |
|
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
|
3 | Q02111 (/ISS) Q05655 (/ISS) Q9WTQ0 (/ISS) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
3 | P23298 (/ISS) Q64617 (/ISS) Q9WTQ0 (/ISS) |
|
Negative regulation of filopodium assembly GO:0051490
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
|
3 | P09215 (/ISS) Q05655 (/ISS) Q5PU49 (/ISS) |
|
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
|
3 | P09216 (/ISS) P10830 (/ISS) P16054 (/ISS) |
|
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
|
3 | P09215 (/ISS) Q05655 (/ISS) Q5PU49 (/ISS) |
|
Cellular response to angiotensin GO:1904385
\Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.\
|
3 | P09215 (/ISS) P28867 (/ISS) Q5PU49 (/ISS) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
2 | P09215 (/IEP) Q9WTQ0 (/IEP) |
|
Receptor recycling GO:0001881
The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
|
2 | F1QJU6 (/IDA) F1QY14 (/IDA) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q04759 (/ISS) Q9WTQ0 (/ISS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
2 | P13678 (/ISS) P23298 (/ISS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
2 | P24723 (/TAS) Q02156 (/TAS) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
2 | H9G2Y7 (/IMP) P34885 (/IMP) |
|
Activation of phospholipase C activity GO:0007202
The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
|
2 | Q02156 (/TAS) Q05655 (/TAS) |
|
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
|
2 | H9G2Y7 (/IMP) P34885 (/IMP) |
|
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
2 | P09215 (/IEP) Q9WTQ0 (/IEP) |
|
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
2 | P09215 (/IEP) Q9WTQ0 (/IEP) |
|
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
2 | P09215 (/IEP) Q9WTQ0 (/IEP) |
|
Positive regulation of macrophage derived foam cell differentiation GO:0010744
Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
|
2 | P24723 (/ISS) Q64617 (/ISS) |
|
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
2 | P09215 (/IEP) Q9WTQ0 (/IEP) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
2 | P09216 (/IMP) P34722 (/IMP) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
2 | P16054 (/ISO) P28867 (/ISO) |
|
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
2 | G8JY36 (/ISS) P90980 (/ISS) |
|
Positive regulation of interleukin-17 production GO:0032740
Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
|
2 | Q04759 (/ISS) Q9WTQ0 (/ISS) |
|
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
|
2 | Q04759 (/ISS) Q9WTQ0 (/ISS) |
|
Negative regulation of glial cell apoptotic process GO:0034351
Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.
|
2 | P24723 (/IMP) Q05655 (/IMP) |
|
Negative regulation of glial cell apoptotic process GO:0034351
Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.
|
2 | P23298 (/ISO) P28867 (/ISO) |
|
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
|
2 | Q02156 (/TAS) Q05655 (/TAS) |
|
Regulation of locomotion GO:0040012
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
|
2 | H9G2Y7 (/IMP) P34885 (/IMP) |
|
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
2 | P09215 (/IMP) P16054 (/IMP) |
|
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
|
2 | P13677 (/IDA) P13678 (/IDA) |
|
Positive regulation of keratinocyte differentiation GO:0045618
Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.
|
2 | P24723 (/ISS) Q64617 (/ISS) |
|
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
|
2 | P28867 (/IMP) Q04759 (/IMP) |
|
Positive regulation of B cell receptor signaling pathway GO:0050861
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
|
2 | P23298 (/ISS) Q64617 (/ISS) |
|
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
|
2 | Q04759 (/ISS) Q9WTQ0 (/ISS) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
2 | P24723 (/IMP) Q02111 (/IMP) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
2 | P23298 (/ISO) Q02111 (/ISO) |
|
Synapse maturation GO:0060074
The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
|
2 | F1QJU6 (/IMP) F1QY14 (/IMP) |
|
Positive regulation of glial cell proliferation GO:0060252
Any process that activates or increases the rate or extent of glial cell proliferation.
|
2 | P23298 (/ISS) Q64617 (/ISS) |
|
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
2 | Q04759 (/IMP) Q05655 (/IMP) |
|
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
2 | P28867 (/ISO) Q02111 (/ISO) |
|
Negative regulation of T cell apoptotic process GO:0070233
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.
|
2 | Q02111 (/ISS) Q9WTQ0 (/ISS) |
|
Regulation of platelet aggregation GO:0090330
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
|
2 | Q04759 (/ISS) Q9WTQ0 (/ISS) |
|
Execution phase of apoptosis GO:0097194
A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
2 | Q04759 (/TAS) Q05655 (/TAS) |
|
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
2 | P24723 (/TAS) Q02156 (/TAS) |
|
Positive regulation of T-helper 17 type immune response GO:2000318
Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response.
|
2 | Q04759 (/ISS) Q9WTQ0 (/ISS) |
|
Positive regulation of clathrin-dependent endocytosis GO:2000370
Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis.
|
2 | P05130 (/IGI) P13677 (/IGI) |
|
Positive regulation of T-helper 2 cell activation GO:2000570
Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation.
|
2 | Q04759 (/ISS) Q9WTQ0 (/ISS) |
|
Regulation of bicellular tight junction assembly GO:2000810
Any process that modulates the frequency, rate or extent of tight junction assembly.
|
2 | P23298 (/ISS) Q64617 (/ISS) |
|
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
|
1 | P34885 (/IMP) |
|
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
1 | Q04759 (/NAS) |
|
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
|
1 | Q05655 (/TAS) |
|
Macrophage activation involved in immune response GO:0002281
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
|
1 | P16054 (/IMP) |
|
Glomerular filtration GO:0003094
The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
|
1 | B8A467 (/IMP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q02111 (/IMP) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | P24723 (/IMP) |
|
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
|
1 | Q02111 (/IDA) |
|
Membrane protein ectodomain proteolysis GO:0006509
The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
|
1 | Q04759 (/ISS) |
|
Phagocytosis GO:0006909
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
|
1 | P13677 (/IMP) |
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
1 | Q05655 (/IDA) |
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
1 | P09215 (/IMP) |
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
1 | P28867 (/ISO) |
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
1 | Q02156 (/TAS) |
|
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | P09215 (/IMP) |
|
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
|
1 | P13678 (/IMP) |
|
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
|
1 | P34885 (/IMP) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q04759 (/TAS) |
|
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
|
1 | P13677 (/IGI) |
|
Sensory perception of chemical stimulus GO:0007606
The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
|
1 | P34885 (/IGI) |
|
Sensory perception of chemical stimulus GO:0007606
The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
|
1 | P34885 (/IMP) |
|
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
1 | P13678 (/IMP) |
|
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
|
1 | P34885 (/IGI) |
|
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
|
1 | P34885 (/IMP) |
|
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
|
1 | P16054 (/TAS) |
|
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P13678 (/IMP) |
|
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
|
1 | P34885 (/IMP) |
|
Female gonad development GO:0008585
The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
|
1 | P13677 (/IMP) |
|
Intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
|
1 | Q05655 (/TAS) |
|
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
|
1 | P13677 (/IMP) |
|
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
|
1 | P34722 (/IMP) |
|
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
|
1 | P09215 (/IEP) |
|
Dorsal/ventral axis specification GO:0009950
The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
1 | P13678 (/IMP) |
|
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
1 | P09215 (/IEP) |
|
Regulation of G2/M transition of mitotic cell cycle GO:0010389
Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle.
|
1 | Q9WTQ0 (/IMP) |
|
Regulation of receptor activity GO:0010469
Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
|
1 | Q05655 (/TAS) |
|
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
|
1 | Q02156 (/IMP) |
|
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
|
1 | P16054 (/ISO) |
|
Positive regulation of macrophage derived foam cell differentiation GO:0010744
Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
|
1 | P23298 (/IMP) |
|
Positive regulation of fibroblast migration GO:0010763
Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
|
1 | P16054 (/IMP) |
|
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
|
1 | P16054 (/IGI) |
|
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
|
1 | P16054 (/IMP) |
|
Negative regulation of mitochondrial membrane potential GO:0010917
Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
1 | P09216 (/IMP) |
|
Aspartate transport GO:0015810
The directed movement of aspartate, the anion of aspartic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P09215 (/IMP) |
|
Deactivation of rhodopsin mediated signaling GO:0016059
The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon).
|
1 | P13677 (/IMP) |
|
Deactivation of rhodopsin mediated signaling GO:0016059
The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon).
|
1 | P13677 (/TAS) |
|
Adaptation of rhodopsin mediated signaling GO:0016062
The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation.
|
1 | P13677 (/IGI) |
|
Adaptation of rhodopsin mediated signaling GO:0016062
The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation.
|
1 | P13677 (/IMP) |
|
Adaptation of rhodopsin mediated signaling GO:0016062
The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation.
|
1 | P13677 (/NAS) |
|
Immunoglobulin mediated immune response GO:0016064
An immune response mediated by immunoglobulins, whether cell-bound or in solution.
|
1 | P28867 (/IMP) |
|
Synaptic vesicle exocytosis GO:0016079
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
|
1 | P34885 (/IMP) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | P13677 (/IMP) |
|
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
|
1 | Q05655 (/IDA) |
|
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
|
1 | P28867 (/ISO) |
|
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
1 | Q05655 (/IDA) |
|
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
1 | P28867 (/ISO) |
|
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
1 | P16054 (/IMP) |
|
Regulation of vasoconstriction GO:0019229
Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.
|
1 | Q9WTQ0 (/IEP) |
|
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
|
1 | P13677 (/TAS) |
|
Termination of signal transduction GO:0023021
The signaling process in which signal transduction is brought to an end rather than being reversibly modulated.
|
1 | Q05655 (/IMP) |
|
Termination of signal transduction GO:0023021
The signaling process in which signal transduction is brought to an end rather than being reversibly modulated.
|
1 | P28867 (/ISO) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
1 | Q9WTQ0 (/IEP) |
|
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
|
1 | P28867 (/IMP) |
|
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
|
1 | P16054 (/IDA) |
|
Phospholipase C-inhibiting G-protein coupled receptor signaling pathway GO:0030845
A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).
|
1 | P13677 (/IMP) |
|
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | P16054 (/IMP) |
|
Lipopolysaccharide-mediated signaling pathway GO:0031663
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
|
1 | P16054 (/IMP) |
|
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
|
1 | P16054 (/IMP) |
|
Positive regulation of endodeoxyribonuclease activity GO:0032079
Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
|
1 | Q05655 (/IMP) |
|
Positive regulation of endodeoxyribonuclease activity GO:0032079
Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
|
1 | P28867 (/ISO) |
|
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
|
1 | Q05655 (/TAS) |
|
Activation of protein kinase activity GO:0032147
Any process that initiates the activity of an inactive protein kinase.
|
1 | Q05655 (/IDA) |
|
Activation of protein kinase activity GO:0032147
Any process that initiates the activity of an inactive protein kinase.
|
1 | P28867 (/ISO) |
|
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
|
1 | Q04759 (/IMP) |
|
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
|
1 | Q02111 (/ISO) |
|
Positive regulation of synaptic transmission, GABAergic GO:0032230
Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
|
1 | P16054 (/IMP) |
|
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
|
1 | Q02156 (/IMP) |
|
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
|
1 | P16054 (/ISO) |
|
Interleukin-10 production GO:0032613
The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
1 | P28867 (/IMP) |
|
Interleukin-12 production GO:0032615
The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
1 | P28867 (/IMP) |
|
Positive regulation of interleukin-17 production GO:0032740
Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
|
1 | Q02111 (/IMP) |
|
Positive regulation of interleukin-4 production GO:0032753
Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
|
1 | Q02111 (/IMP) |
|
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | Q9WTQ0 (/IEP) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | P09215 (/IEP) |
|
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
|
1 | Q05655 (/IMP) |
|
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
|
1 | P28867 (/ISO) |
|
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q05655 (/IMP) |
|
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | P28867 (/ISO) |
|
Collagen metabolic process GO:0032963
The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
1 | P09215 (/IMP) |
|
Lipid particle organization GO:0034389
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
|
1 | P13678 (/IMP) |
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | P09215 (/IDA) |
|
Regulation of hemocyte proliferation GO:0035206
Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
|
1 | P05130 (/IMP) |
|
Positive regulation of protein dephosphorylation GO:0035307
Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.
|
1 | Q05655 (/IMP) |
|
Positive regulation of protein dephosphorylation GO:0035307
Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.
|
1 | P28867 (/ISO) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
1 | Q02111 (/IMP) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
1 | Q04759 (/NAS) |
|
Locomotory exploration behavior GO:0035641
The specific movement from place to place of an organism in response to a novel environment.
|
1 | P16054 (/IGI) |
|
TRAM-dependent toll-like receptor 4 signaling pathway GO:0035669
Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
|
1 | P16054 (/IMP) |
|
Cellular response to platelet-derived growth factor stimulus GO:0036120
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
|
1 | P09216 (/IMP) |
|
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
|
1 | Q04759 (/TAS) |
|
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
1 | P13678 (/IMP) |
|
Dauer larval development GO:0040024
The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
|
1 | P34885 (/IMP) |
|
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
|
1 | P28867 (/IMP) |
|
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
1 | Q02111 (/IMP) |
|
Neutrophil activation GO:0042119
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
|
1 | Q05655 (/IDA) |
|
Neutrophil activation GO:0042119
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
|
1 | P28867 (/ISO) |
|
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
|
1 | P09215 (/IEP) |
|
Tissue regeneration GO:0042246
The regrowth of lost or destroyed tissues.
|
1 | Q9WTQ0 (/IEP) |
|
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
1 | Q05655 (/IMP) |
|
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
1 | P28867 (/ISO) |
|
Regulation of phosphorylation GO:0042325
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
|
1 | P09215 (/IDA) |
|
Positive regulation of NF-kappaB import into nucleus GO:0042346
Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
|
1 | Q9WTQ0 (/IMP) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P09215 (/IEP) |
|
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | P09215 (/IEP) |
|
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
|
1 | P28867 (/IMP) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | P09215 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P09216 (/IMP) |
|
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
|
1 | P16054 (/IMP) |
|
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
|
1 | P09215 (/IEP) |
|
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
|
1 | P16054 (/IMP) |
|
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
1 | Q05655 (/TAS) |
|
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
|
1 | P09215 (/IMP) |
|
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
|
1 | Q05655 (/IMP) |
|
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
|
1 | P28867 (/ISO) |
|
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
1 | P16054 (/IDA) |
|
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
|
1 | Q05655 (/TAS) |
|
Positive regulation of interleukin-2 biosynthetic process GO:0045086
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.
|
1 | Q02111 (/IMP) |
|
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
|
1 | P09215 (/IEP) |
|
Positive regulation of keratinocyte differentiation GO:0045618
Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.
|
1 | P23298 (/IMP) |
|
Respiratory burst GO:0045730
A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
|
1 | Q9WTQ0 (/IEP) |
|
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
|
1 | P09215 (/IMP) |
|
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
|
1 | Q02111 (/ISO) |
|
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
|
1 | Q05655 (/TAS) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
1 | P09215 (/IDA) |
|
Insulin-like growth factor receptor signaling pathway GO:0048009
The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.
|
1 | P34885 (/IMP) |
|
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
|
1 | P13678 (/IMP) |
|
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
|
1 | Q9WTQ0 (/IDA) |
|
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
1 | Q05655 (/IC) |
|
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
1 | P16054 (/IMP) |
|
Negative regulation of peptidyl-tyrosine phosphorylation GO:0050732
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
1 | P28867 (/IMP) |
|
Negative regulation of peptidyl-tyrosine phosphorylation GO:0050732
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
1 | Q05655 (/ISS) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | Q05655 (/NAS) |
|
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
|
1 | P34722 (/IMP) |
|
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
|
1 | Q04759 (/TAS) |
|
Positive regulation of B cell receptor signaling pathway GO:0050861
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
|
1 | P24723 (/IMP) |
|
Positive regulation of B cell receptor signaling pathway GO:0050861
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
|
1 | P23298 (/ISO) |
|
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
|
1 | Q02111 (/IMP) |
|
Sensory processing GO:0050893
Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect.
|
1 | P34885 (/IGI) |
|
Sensory processing GO:0050893
Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect.
|
1 | P34885 (/IMP) |
|
Regulation of chemotaxis GO:0050920
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
|
1 | P34885 (/IGI) |
|
Positive regulation of positive chemotaxis GO:0050927
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
|
1 | P34885 (/IMP) |
|
Detection of light stimulus involved in sensory perception GO:0050962
The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light.
|
1 | P13677 (/IMP) |
|
Sensory perception of touch GO:0050975
The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).
|
1 | P34885 (/IMP) |
|
Positive regulation of lipid catabolic process GO:0050996
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
|
1 | P16054 (/IMP) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | Q04759 (/IDA) |
|
Release of sequestered calcium ion into cytosol GO:0051209
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
|
1 | P16054 (/IMP) |
|
Regulation of release of sequestered calcium ion into cytosol GO:0051279
Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
|
1 | P16054 (/IDA) |
|
Negative regulation of release of sequestered calcium ion into cytosol GO:0051280
Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
|
1 | P09216 (/IMP) |
|
Negative regulation of filopodium assembly GO:0051490
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
|
1 | P28867 (/IMP) |
|
Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
|
1 | Q9WTQ0 (/IMP) |
|
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
1 | Q9WTQ0 (/IMP) |
|
Negative regulation of mitochondrial calcium ion concentration GO:0051562
Any process that decreases the concentration of calcium ions in mitochondria.
|
1 | P09216 (/IMP) |
|
Positive regulation of telomerase activity GO:0051973
Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
1 | Q04759 (/IMP) |
|
Positive regulation of telomerase activity GO:0051973
Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
1 | Q02111 (/ISO) |
|
Positive regulation of glial cell proliferation GO:0060252
Any process that activates or increases the rate or extent of glial cell proliferation.
|
1 | P24723 (/IMP) |
|
Positive regulation of glial cell proliferation GO:0060252
Any process that activates or increases the rate or extent of glial cell proliferation.
|
1 | P23298 (/ISO) |
|
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
|
1 | Q05655 (/TAS) |
|
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
|
1 | P16054 (/IMP) |
|
Negative regulation of T cell apoptotic process GO:0070233
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.
|
1 | Q04759 (/IMP) |
|
Negative regulation of T cell apoptotic process GO:0070233
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.
|
1 | Q02111 (/ISO) |
|
Positive regulation of mucus secretion GO:0070257
Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.
|
1 | P16054 (/IMP) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | Q05655 (/IDA) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | P28867 (/ISO) |
|
Protein kinase C signaling GO:0070528
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
|
1 | Q64617 (/IMP) |
|
Cellular response to ethanol GO:0071361
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
|
1 | P16054 (/IGI) |
|
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
|
1 | P16054 (/IDA) |
|
Cellular response to hydroperoxide GO:0071447
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
|
1 | Q05655 (/IDA) |
|
Cellular response to hydroperoxide GO:0071447
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
|
1 | P28867 (/ISO) |
|
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P16054 (/IDA) |
|
Glomerular visceral epithelial cell development GO:0072015
The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
|
1 | B8A467 (/IMP) |
|
Positive regulation of peptide hormone secretion GO:0090277
Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.
|
1 | P13678 (/IMP) |
|
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
|
1 | Q02156 (/IMP) |
|
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
|
1 | P16054 (/ISO) |
|
Regulation of platelet aggregation GO:0090330
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
|
1 | Q02111 (/IMP) |
|
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
|
1 | P28867 (/IMP) |
|
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
|
1 | Q05655 (/IMP) |
|
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
|
1 | P28867 (/ISO) |
|
Positive regulation of phospholipid scramblase activity GO:1900163
Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity.
|
1 | Q05655 (/IMP) |
|
Positive regulation of phospholipid scramblase activity GO:1900163
Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity.
|
1 | P28867 (/ISO) |
|
Response to salt GO:1902074
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.
|
1 | P34885 (/IGI) |
|
Response to salt GO:1902074
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.
|
1 | P34885 (/IMP) |
|
Positive regulation of telomere capping GO:1904355
Any process that activates or increases the frequency, rate or extent of telomere capping.
|
1 | Q04759 (/IMP) |
|
Positive regulation of telomere capping GO:1904355
Any process that activates or increases the frequency, rate or extent of telomere capping.
|
1 | Q02111 (/ISO) |
|
Cellular response to angiotensin GO:1904385
\Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.\
|
1 | Q05655 (/IDA) |
|
Cellular response to angiotensin GO:1904385
\Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.\
|
1 | P28867 (/ISO) |
|
Positive regulation of MAPK cascade involved in axon regeneration GO:1904922
Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in axon regeneration.
|
1 | P34722 (/IMP) |
|
Dense core granule exocytosis GO:1990504
The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
|
1 | P34885 (/IMP) |
|
Positive regulation of ceramide biosynthetic process GO:2000304
Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process.
|
1 | Q05655 (/IMP) |
|
Positive regulation of ceramide biosynthetic process GO:2000304
Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process.
|
1 | P28867 (/ISO) |
|
Positive regulation of T-helper 17 type immune response GO:2000318
Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response.
|
1 | Q02111 (/IMP) |
|
Positive regulation of T-helper 2 cell activation GO:2000570
Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation.
|
1 | Q02111 (/IMP) |
|
Negative regulation of sodium ion transmembrane transporter activity GO:2000650
Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity.
|
1 | Q02156 (/TAS) |
|
Positive regulation of glucosylceramide catabolic process GO:2000753
Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process.
|
1 | Q05655 (/IMP) |
|
Positive regulation of glucosylceramide catabolic process GO:2000753
Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process.
|
1 | P28867 (/ISO) |
|
Positive regulation of sphingomyelin catabolic process GO:2000755
Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process.
|
1 | Q05655 (/IMP) |
|
Positive regulation of sphingomyelin catabolic process GO:2000755
Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process.
|
1 | P28867 (/ISO) |
|
Regulation of bicellular tight junction assembly GO:2000810
Any process that modulates the frequency, rate or extent of tight junction assembly.
|
1 | P24723 (/IMP) |
|
Regulation of bicellular tight junction assembly GO:2000810
Any process that modulates the frequency, rate or extent of tight junction assembly.
|
1 | P23298 (/ISO) |
|
Positive regulation of response to DNA damage stimulus GO:2001022
Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus.
|
1 | Q05655 (/IMP) |
|
Positive regulation of response to DNA damage stimulus GO:2001022
Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus.
|
1 | P28867 (/ISO) |
|
Negative regulation of response to drug GO:2001024
Any process that stops, prevents or reduces the frequency, rate or extent of response to drug.
|
1 | P34885 (/IMP) |
|
Positive regulation of cellular glucuronidation GO:2001031
Any process that activates or increases the frequency, rate or extent of cellular glucuronidation.
|
1 | Q02156 (/IMP) |
|
Positive regulation of cellular glucuronidation GO:2001031
Any process that activates or increases the frequency, rate or extent of cellular glucuronidation.
|
1 | P16054 (/ISO) |
|
Positive regulation of apoptotic signaling pathway GO:2001235
Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
|
1 | P28867 (/IDA) |
There are 43 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
10 | A0A024R328 (/IDA) G8JY36 (/IDA) P09215 (/IDA) P09216 (/IDA) P16054 (/IDA) P23298 (/IDA) P90980 (/IDA) Q02156 (/IDA) Q05655 (/IDA) Q64617 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
8 | P09215 (/IDA) P16054 (/IDA) P24723 (/IDA) P28867 (/IDA) Q02111 (/IDA) Q02156 (/IDA) Q05655 (/IDA) Q9WTQ0 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
8 | P09215 (/IDA) P09216 (/IDA) P13677 (/IDA) P23298 (/IDA) P24723 (/IDA) Q02111 (/IDA) Q02156 (/IDA) Q05655 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
7 | G8JY36 (/IDA) P09215 (/IDA) P16054 (/IDA) P28867 (/IDA) P90980 (/IDA) Q64617 (/IDA) Q9WTQ0 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | P09215 (/IDA) P16054 (/IDA) P28867 (/IDA) Q05655 (/IDA) Q9WTQ0 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | P24723 (/TAS) Q02156 (/TAS) Q04759 (/TAS) Q05655 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P05130 (/ISS) P13678 (/ISS) P83099 (/ISS) W5UK87 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | P16054 (/ISO) P23298 (/ISO) P28867 (/ISO) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | P09215 (/ISS) P28867 (/ISS) Q5PU49 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P16054 (/ISO) P23298 (/ISO) P28867 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q02156 (/TAS) Q04759 (/TAS) Q05655 (/TAS) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
3 | P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) |
|
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
3 | P09216 (/ISS) P10830 (/ISS) Q02156 (/ISS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P09215 (/IDA) P16054 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | Q02156 (/IDA) Q05655 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | P16054 (/ISO) P28867 (/ISO) |
|
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
|
2 | A0A087X0I9 (/IDA) Q04759 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P16054 (/ISO) P28867 (/ISO) |
|
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
2 | P23298 (/IDA) P28867 (/IDA) |
|
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
|
2 | A0A087X0I9 (/IDA) Q04759 (/IDA) |
|
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
2 | G8JY36 (/IDA) P90980 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | G8JY36 (/IDA) P90980 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | P24723 (/IDA) Q05655 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | P23298 (/ISO) P28867 (/ISO) |
|
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
|
1 | P09216 (/IDA) |
|
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
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1 | Q02111 (/IDA) |
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Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
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1 | Q05655 (/TAS) |
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Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
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1 | P34885 (/IMP) |
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Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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1 | P28867 (/ISO) |
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Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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1 | Q5PU49 (/ISS) |
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Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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1 | Q05655 (/TAS) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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1 | Q5PU49 (/ISS) |
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Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
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1 | Q02111 (/ISO) |
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Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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1 | P24723 (/ISS) |
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InaD signaling complex GO:0016027
A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.
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1 | P13677 (/TAS) |
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Rhabdomere GO:0016028
The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
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1 | P13677 (/IDA) |
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Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
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1 | Q02111 (/ISO) |
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Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
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1 | P28867 (/IDA) |
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Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
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1 | Q9WTQ0 (/IDA) |
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Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
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1 | Q05655 (/TAS) |
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Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
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1 | Q9WTQ0 (/IDA) |
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Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
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1 | P16054 (/IDA) |
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Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
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1 | P16054 (/IDA) |