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CATH Superfamily 3.30.1660.20

Resistin head domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Resistin head domain

Structural domains comprising this superfamily share the structure of the head domain of resistin, the founding member of the resistin-like molecule (RELM) hormone family, which is selectively secreted from adipocytes and induces liver-specific antagonism of insulin action. Resistin is a two domain protein with each protomer being composed of a disulfide rich beta-sandwich C terminal head domain linked to an N terminal helical tail. These protomers assemble to form trimer-dimer hexamers PMID:15155948.

GO Diversity

Unique GO annotations
22 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
117 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 12
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 1
Unique GO: 22
Taxonomy
Unique Species: 117