The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Classic Zinc Finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23366: Kruppel-like factor 1 (Erythroid)

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 97 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Double-stranded methylated DNA binding GO:0010385
Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
24 A0A1D5PEL8 (/ISS) A4II20 (/ISS) A9CSE6 (/ISS) A9CSE8 (/ISS) B5DE03 (/ISS) B7ZSG3 (/ISS) F1NF76 (/ISS) O42223 (/ISS) O62651 (/ISS) O73691 (/ISS)
(14 more)
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
24 A0A1D5PEL8 (/ISS) A4II20 (/ISS) A9CSE6 (/ISS) A9CSE8 (/ISS) B5DE03 (/ISS) B7ZSG3 (/ISS) F1NF76 (/ISS) O42223 (/ISS) O62651 (/ISS) O73691 (/ISS)
(14 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
21 A0A1D5PEL8 (/ISS) A4II20 (/ISS) B5DE03 (/ISS) B7ZSG3 (/ISS) F1NF76 (/ISS) O62651 (/ISS) O73691 (/ISS) O73692 (/ISS) O73693 (/ISS) O73694 (/ISS)
(11 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
20 A0A1D5PEL8 (/ISS) A4II20 (/ISS) B5DE03 (/ISS) B7ZSG3 (/ISS) F1NF76 (/ISS) O62651 (/ISS) O73691 (/ISS) O73692 (/ISS) O73693 (/ISS) O73694 (/ISS)
(10 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
19 F1LSL7 (/IPI) O35738 (/IPI) P08152 (/IPI) P11161 (/IPI) P18146 (/IPI) P19544 (/IPI) P22561 (/IPI) P49952 (/IPI) P57682 (/IPI) Q13887 (/IPI)
(9 more)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
17 A1XSY8 (/ISS) A4II20 (/ISS) O62651 (/ISS) O73691 (/ISS) O73692 (/ISS) O73693 (/ISS) O73694 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS)
(7 more)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
13 A0A1D5PEL8 (/ISS) A1XSY8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P11161 (/ISS) P22561 (/ISS) P26633 (/ISS) P26634 (/ISS) P49952 (/ISS) P49953 (/ISS)
(3 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
12 F1LSL7 (/IDA) P08154 (/IDA) P18146 (/IDA) P19544 (/IDA) P49952 (/IDA) Q60793 (/IDA) Q66HP1 (/IDA) Q8MR37 (/IDA) Q923V7 (/IDA) Q9ET58 (/IDA)
(2 more)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
11 O35738 (/IDA) P08046 (/IDA) P08152 (/IDA) P11161 (/IDA) P18146 (/IDA) P22561 (/IDA) Q60793 (/IDA) Q923V7 (/IDA) Q99JB0 (/IDA) Q9Y4X4 (/IDA)
(1 more)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
11 A4II20 (/ISS) O73691 (/ISS) O73692 (/ISS) O73693 (/ISS) O73694 (/ISS) P08046 (/ISS) P26632 (/ISS) Q29W20 (/ISS) Q60793 (/ISS) Q6GQH4 (/ISS)
(1 more)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
9 O75840 (/IDA) P08154 (/IDA) P11161 (/IDA) P22561 (/IDA) P46099 (/IDA) Q13887 (/IDA) Q60793 (/IDA) Q923V7 (/IDA) Q99612 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
9 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA) Q60843 (/ISA) Q9I8A0 (/ISA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
8 O35738 (/IDA) P08046 (/IDA) P08152 (/IDA) P18146 (/IDA) Q99JB0 (/IDA) Q9DFS2 (/IDA) Q9Y4X4 (/IDA) Q9Z0Z7 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
8 O35738 (/ISS) P46099 (/ISS) Q60793 (/ISS) Q60843 (/ISS) Q60980 (/ISS) Q8BLM0 (/ISS) Q99JB0 (/ISS) Q9Z0Z7 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
8 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA) Q9I8A0 (/ISA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
7 P08046 (/IDA) P08152 (/IDA) P19544 (/IDA) Q13351 (/IDA) Q1LXI7 (/IDA) Q60793 (/IDA) Q923V7 (/IDA)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
6 O75840 (/IDA) O95600 (/IDA) P11161 (/IDA) P46099 (/IDA) Q13887 (/IDA) Q99612 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 O73691 (/TAS) O73692 (/TAS) O73693 (/TAS) O73694 (/TAS) P51774 (/TAS) Q8QG62 (/TAS)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
5 O35738 (/IDA) P08046 (/IDA) P08154 (/IDA) P18146 (/IDA) Q00911 (/IDA)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
5 A1XSY8 (/ISS) P11161 (/ISS) P26633 (/ISS) P26634 (/ISS) P51774 (/ISS)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
4 O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
4 O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
4 P08152 (/ISO) Q8BLM0 (/ISO) Q99JB0 (/ISO) Q9Z0Z7 (/ISO)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
4 P08152 (/ISO) Q60793 (/ISO) Q99JB0 (/ISO) Q9Z0Z7 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
4 O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
4 P08152 (/IMP) P08154 (/IMP) Q9ET58 (/IMP) Q9Z0Z7 (/IMP)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
4 O35738 (/ISO) P08046 (/ISO) P08152 (/ISO) Q60843 (/ISO)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
4 O75840 (/TAS) Q06889 (/TAS) Q13351 (/TAS) Q9Y4X4 (/TAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
4 F1LSL7 (/IPI) P08154 (/IPI) Q60793 (/IPI) Q66HP1 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
4 O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
C2H2 zinc finger domain binding GO:0070742
Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 O35738 (/ISO) P08046 (/ISO) Q60843 (/ISO)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
3 P08154 (/IDA) P22561 (/IDA) Q923V7 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
3 P19544 (/NAS) P57682 (/NAS) Q05215 (/NAS)
C2H2 zinc finger domain binding GO:0070742
Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.
3 O62651 (/ISS) P22561 (/ISS) P49952 (/ISS)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2 P08046 (/IMP) P08154 (/IMP)
Core promoter proximal region sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon.
2 P46099 (/ISO) Q60793 (/ISO)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
2 P08046 (/IMP) P46099 (/IMP)
Transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001227
Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O35738 (/IDA) Q90XE9 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P08152 (/IDA) Q90XE9 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 P18146 (/IDA) P19544 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 P08046 (/ISO) P22561 (/ISO)
Double-stranded methylated DNA binding GO:0010385
Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
2 P18146 (/IDA) P19544 (/IDA)
Double-stranded methylated DNA binding GO:0010385
Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
2 P08046 (/ISO) P22561 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 P08046 (/ISO) P22561 (/ISO)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 P22561 (/ISO) P46099 (/ISO)
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
2 P18146 (/IDA) P19544 (/IDA)
Hemi-methylated DNA-binding GO:0044729
Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
2 P08046 (/ISO) P22561 (/ISO)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
2 P08154 (/IDA) P18146 (/IDA)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
2 P08046 (/ISO) Q60793 (/ISO)
Regulatory region DNA binding GO:0000975
Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair.
1 Q60793 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 P18146 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 P08046 (/ISO)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 P08046 (/ISO)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery.
1 P08154 (/IDA)
RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 Q9Y5W3 (/IMP)
RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 Q60843 (/ISO)
Transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000982
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.
1 P08046 (/IDA)
Core promoter proximal region sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon.
1 Q13351 (/IDA)
Transcription factor activity, sequence-specific DNA binding transcription factor recruiting GO:0001010
The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions.
1 Q60793 (/IDA)
Core promoter binding GO:0001047
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q60793 (/IDA)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 Q9UIH9 (/IC)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 Q60793 (/NAS)
Transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O95600 (/IDA)
Transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O95600 (/IMP)
Transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8BLM0 (/ISO)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 Q60793 (/IPI)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 Q60793 (/ISO)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
1 P08152 (/IPI)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
1 P11161 (/ISS)
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
1 Q5TYN4 (/IDA)
Transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001190
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
1 Q60793 (/ISO)
Transcription cofactor binding GO:0001221
Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
1 Q923V7 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9Y5W3 (/IMP)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 O75840 (/TAS)
Transcription corepressor activity GO:0003714
Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
1 Q9Y4X4 (/TAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P22561 (/IDA)
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
1 Q60793 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q9I8A0 (/NAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 O75840 (/TAS)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P46099 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P11161 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P08152 (/ISO)
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
1 P46099 (/IPI)
Phosphatidylinositol 3-kinase regulator activity GO:0035014
Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
1 Q923V7 (/IMP)
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
1 P18146 (/IPI)
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
1 P08046 (/ISO)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
1 Q923V7 (/IPI)
C2H2 zinc finger domain binding GO:0070742
Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.
1 P19544 (/IPI)
C2H2 zinc finger domain binding GO:0070742
Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.
1 P22561 (/ISO)
HMG box domain binding GO:0071837
Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.
1 P51774 (/IPI)

There are 488 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
18 A0A1D5PEL8 (/ISS) A1XSY8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) O73691 (/ISS) O73692 (/ISS) O73693 (/ISS) O73694 (/ISS) P11161 (/ISS) P22561 (/ISS)
(8 more)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
16 O35738 (/IDA) O75840 (/IDA) P08046 (/IDA) P08152 (/IDA) P08154 (/IDA) P11161 (/IDA) P18146 (/IDA) P22561 (/IDA) P46099 (/IDA) Q00911 (/IDA)
(6 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
13 P08046 (/IDA) P08152 (/IDA) P18146 (/IDA) P19544 (/IDA) P22561 (/IDA) P46099 (/IDA) P49952 (/IDA) Q13351 (/IDA) Q60793 (/IDA) Q60843 (/IDA)
(3 more)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
10 P08046 (/IMP) P08154 (/IMP) P18146 (/IMP) P46099 (/IMP) P49952 (/IMP) Q60793 (/IMP) Q60843 (/IMP) Q9UIH9 (/IMP) Q9VZN4 (/IMP) Q9Y5W3 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
10 A4II20 (/ISS) O73691 (/ISS) O73692 (/ISS) O73693 (/ISS) O73694 (/ISS) P26632 (/ISS) Q29W20 (/ISS) Q60793 (/ISS) Q6GQH4 (/ISS) Q6NTY6 (/ISS)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
9 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O42223 (/ISS) O62651 (/ISS) P22561 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS) Q9I8A0 (/ISS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
9 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O42223 (/ISS) O62651 (/ISS) P22561 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS) Q9I8A0 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
9 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P22561 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS) Q60793 (/ISS) Q923V7 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
8 A4II20 (/ISS) O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS) Q6GQH4 (/ISS) Q6NTY6 (/ISS)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
8 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA) Q9I8A0 (/ISA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
8 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA) Q9I8A0 (/ISA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
8 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA) Q9I8A0 (/ISA)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
7 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P22561 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Cellular response to gonadotropin stimulus GO:0071371
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
7 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P22561 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Cellular response to interleukin-8 GO:0098759
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus.
7 O73691 (/ISS) O73692 (/ISS) O73693 (/ISS) O73694 (/ISS) P08046 (/ISS) P08154 (/ISS) Q29W20 (/ISS)
Branching involved in ureteric bud morphogenesis GO:0001658
The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
6 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
6 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS) Q9VZN4 (/ISS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
6 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Sex determination GO:0007530
Any process that establishes and transmits the specification of sexual status of an individual organism.
6 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Adrenal gland development GO:0030325
The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
6 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
6 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
6 P08046 (/ISO) P08152 (/ISO) Q60793 (/ISO) Q60843 (/ISO) Q99JB0 (/ISO) Q9Z0Z7 (/ISO)
Visceral serous pericardium development GO:0061032
The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.
6 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Glomerular visceral epithelial cell differentiation GO:0072112
The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
6 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS) Q9UIH9 (/ISS)
Metanephric S-shaped body morphogenesis GO:0072284
The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.
6 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Cellular response to peptide GO:1901653
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
6 D4A4V3 (/IEP) F1LSL7 (/IEP) G3V6F3 (/IEP) Q66HP1 (/IEP) Q923V7 (/IEP) Q9ET58 (/IEP)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
5 O35738 (/IDA) P08046 (/IDA) P19544 (/IDA) Q9Y4X4 (/IDA) Q9Z0Z7 (/IDA)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Regulation of animal organ formation GO:0003156
Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
5 A1XSY8 (/ISS) P11161 (/ISS) P26633 (/ISS) P26634 (/ISS) P51774 (/ISS)
Phagocytosis GO:0006909
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
5 A0A0B4KGW2 (/IMP) E1JIP0 (/IMP) Q26452 (/IMP) Q8IN91 (/IMP) Q9VED3 (/IMP)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Thorax and anterior abdomen determination GO:0007356
Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Germ-band shortening GO:0007390
The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo.
5 A0A0B4KGW2 (/IMP) E1JIP0 (/IMP) Q26452 (/IMP) Q8IN91 (/IMP) Q9VED3 (/IMP)
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
5 A0A0B4KGW2 (/IMP) E1JIP0 (/IMP) Q26452 (/IMP) Q8IN91 (/IMP) Q9VED3 (/IMP)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
5 A0A0B4KGW2 (/IMP) E1JIP0 (/IMP) Q26452 (/IMP) Q8IN91 (/IMP) Q9VED3 (/IMP)
Epithelial cell migration, open tracheal system GO:0007427
The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster.
5 A0A0B4KGW2 (/IGI) E1JIP0 (/IGI) Q26452 (/IGI) Q8IN91 (/IGI) Q9VED3 (/IGI)
Epithelial cell migration, open tracheal system GO:0007427
The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster.
5 A0A0B4KGW2 (/IMP) E1JIP0 (/IMP) Q26452 (/IMP) Q8IN91 (/IMP) Q9VED3 (/IMP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
5 A0A0B4KGW2 (/IMP) E1JIP0 (/IMP) Q26452 (/IMP) Q8IN91 (/IMP) Q9VED3 (/IMP)
Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
5 A0A0B4KGW2 (/IMP) E1JIP0 (/IMP) Q26452 (/IMP) Q8IN91 (/IMP) Q9VED3 (/IMP)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Tissue development GO:0009888
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Regulation of glucose metabolic process GO:0010906
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
5 A0A0B4KGW2 (/IMP) E1JIP0 (/IMP) Q26452 (/IMP) Q8IN91 (/IMP) Q9VED3 (/IMP)
Determination of muscle attachment site GO:0016204
The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site.
5 A0A0B4KGW2 (/TAS) E1JIP0 (/TAS) Q26452 (/TAS) Q8IN91 (/TAS) Q9VED3 (/TAS)
Male genitalia development GO:0030539
The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Adrenal cortex formation GO:0035802
The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate).
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Pigment metabolic process GO:0042440
The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.
5 A0A0B4KGW2 (/TAS) E1JIP0 (/TAS) Q26452 (/TAS) Q8IN91 (/TAS) Q9VED3 (/TAS)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 P08046 (/IMP) P08154 (/IMP) P22561 (/IMP) Q9ET58 (/IMP) Q9Z0Z7 (/IMP)
Mesenchymal to epithelial transition GO:0060231
A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Positive regulation of heart growth GO:0060421
Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Diaphragm development GO:0060539
The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Metanephric mesenchyme development GO:0072075
The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Posterior mesonephric tubule development GO:0072166
The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Negative regulation of metanephric glomerular mesangial cell proliferation GO:0072302
Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Positive regulation of male gonad development GO:2000020
Any process that activates or increases the frequency, rate or extent of male gonad development.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Negative regulation of female gonad development GO:2000195
Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Positive regulation of metanephric ureteric bud development GO:2001076
Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development.
5 O62651 (/ISS) P19544 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 O35738 (/ISO) P22561 (/ISO) Q60793 (/ISO) Q8BLM0 (/ISO)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 A0A1D5PEL8 (/ISS) B5DE03 (/ISS) F1NF76 (/ISS) P79958 (/ISS)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Metanephros development GO:0001656
The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Branching involved in ureteric bud morphogenesis GO:0001658
The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Mesonephros development GO:0001823
The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Regulation of animal organ formation GO:0003156
Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Thorax and anterior abdomen determination GO:0007356
Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Sex determination GO:0007530
Any process that establishes and transmits the specification of sexual status of an individual organism.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
4 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P49952 (/ISS)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Tissue development GO:0009888
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Adrenal gland development GO:0030325
The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Male genitalia development GO:0030539
The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Glomerular basement membrane development GO:0032836
The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Glomerular basement membrane development GO:0032836
The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.
4 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P49952 (/ISS)
Regulation of protein sumoylation GO:0033233
Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein.
4 O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA)
Adrenal cortex formation GO:0035802
The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate).
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
4 O62651 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 P08046 (/ISO) P22561 (/ISO) P46099 (/ISO) Q60843 (/ISO)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
4 A0A0R4ILJ0 (/IMP) B7ZSG3 (/IMP) Q1L884 (/IMP) Q9PUT7 (/IMP)
Sertoli cell development GO:0060009
The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Mesenchymal to epithelial transition GO:0060231
A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Positive regulation of heart growth GO:0060421
Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Cardiac muscle cell fate commitment GO:0060923
The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Visceral serous pericardium development GO:0061032
The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Cellular response to gonadotropin stimulus GO:0071371
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
4 F1LSL7 (/IEP) Q66HP1 (/IEP) Q923V7 (/IEP) Q9ET58 (/IEP)
Cellular response to heparin GO:0071504
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.
4 B8QHP7 (/ISS) P08046 (/ISS) P18146 (/ISS) Q29W20 (/ISS)
Cellular response to mycophenolic acid GO:0071506
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus.
4 B8QHP7 (/ISS) P08046 (/ISS) P18146 (/ISS) Q29W20 (/ISS)
Glomerular visceral epithelial cell development GO:0072015
The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Metanephric mesenchyme development GO:0072075
The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Glomerular mesangial cell proliferation GO:0072110
The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population.
4 B8QHP7 (/ISS) P08046 (/ISS) P18146 (/ISS) Q29W20 (/ISS)
Glomerular visceral epithelial cell differentiation GO:0072112
The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Posterior mesonephric tubule development GO:0072166
The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Metanephric epithelium development GO:0072207
The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Metanephric comma-shaped body morphogenesis GO:0072278
The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Metanephric S-shaped body morphogenesis GO:0072284
The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of metanephric glomerular mesangial cell proliferation GO:0072302
Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Positive regulation of glomerular metanephric mesangial cell proliferation GO:0072303
Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.
4 B8QHP7 (/ISS) P08046 (/ISS) P18146 (/ISS) Q29W20 (/ISS)
Seminiferous tubule development GO:0072520
The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212
Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Positive regulation of male gonad development GO:2000020
Any process that activates or increases the frequency, rate or extent of male gonad development.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of female gonad development GO:2000195
Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Positive regulation of metanephric ureteric bud development GO:2001076
Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 B7ZSG3 (/IMP) O95600 (/IMP) Q9VZN4 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
3 P08154 (/ISS) P18146 (/ISS) Q29W20 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 P08046 (/IMP) P08152 (/IMP) Q13351 (/IMP)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 B7ZSG3 (/IMP) P79958 (/IMP) Q9Z0Z7 (/IMP)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
3 P08152 (/IDA) P18146 (/IDA) Q60793 (/IDA)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
3 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS)
Response to auditory stimulus GO:0010996
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus.
3 A0MWD2 (/IDA) J7JV33 (/IDA) O73693 (/IDA)
Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
3 P08046 (/IMP) P08152 (/IMP) Q9Z0Z7 (/IMP)
Erythrocyte maturation GO:0043249
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
3 P46099 (/IMP) Q60843 (/IMP) Q90XE9 (/IMP)
Estrous cycle GO:0044849
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
3 P08154 (/ISS) P18146 (/ISS) Q29W20 (/ISS)
Positive regulation of chemokine biosynthetic process GO:0045080
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.
3 P08154 (/ISS) P18146 (/ISS) Q29W20 (/ISS)
Positive regulation of hormone biosynthetic process GO:0046886
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.
3 P08154 (/ISS) P18146 (/ISS) Q29W20 (/ISS)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
3 A0A0R4ILJ0 (/IGI) Q1L884 (/IGI) Q9PUT7 (/IGI)
Positive regulation of interleukin-1 beta biosynthetic process GO:0050725
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta.
3 P08154 (/ISS) P18146 (/ISS) Q29W20 (/ISS)
Diaphragm development GO:0060539
The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.
3 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA)
Glomerular visceral epithelial cell differentiation GO:0072112
The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
3 A0A0R4ILJ0 (/IGI) Q1L884 (/IGI) Q9PUT7 (/IGI)
Regulation of progesterone biosynthetic process GO:2000182
Any process that modulates the frequency, rate or extent of progesterone biosynthetic process.
3 P08154 (/ISS) P18146 (/ISS) Q29W20 (/ISS)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
2 P46099 (/IMP) Q60843 (/IMP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
2 A0A1D5PEL8 (/ISS) F1NF76 (/ISS)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
2 P18146 (/ISS) Q29W20 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 O35738 (/IDA) P22561 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 P19544 (/NAS) Q9I8A0 (/NAS)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P22561 (/IDA) Q60793 (/IDA)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O75840 (/TAS) Q9Y4X4 (/TAS)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
2 P22561 (/IMP) Q9TZ64 (/IMP)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
2 P08154 (/IEP) P51774 (/IEP)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 F1LSL7 (/IEP) Q66HP1 (/IEP)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 P19544 (/IDA) Q60793 (/IDA)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
2 A9CSE6 (/IEP) A9CSE8 (/IEP)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
2 B5DE03 (/ISS) P79958 (/ISS)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
2 Q13351 (/IMP) Q9DFS2 (/IMP)
Adrenal gland development GO:0030325
The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
2 P19544 (/IGI) Q9PUT7 (/IGI)
Adrenal gland development GO:0030325
The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
2 P22561 (/IMP) Q9PUT7 (/IMP)
Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
2 P22561 (/IMP) Q9PUT7 (/IMP)
Vulval development GO:0040025
The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
2 P91329 (/IMP) Q65ZG6 (/IMP)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
2 P22561 (/IMP) P26632 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 A9CSE6 (/ISA) A9CSE8 (/ISA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P22561 (/IMP) Q06889 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P22561 (/ISO) P43300 (/ISO)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
2 Q60793 (/ISO) Q60843 (/ISO)
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
2 P08152 (/IMP) Q60793 (/IMP)
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
2 Q8VCZ7 (/IMP) Q9Z0Z7 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P19544 (/IDA) P22561 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P22561 (/ISO) Q60793 (/ISO)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P18146 (/IGI) Q9Y5W3 (/IGI)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
2 B7ZSG3 (/IEP) P79958 (/IEP)
Positive regulation of protein metabolic process GO:0051247
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
2 Q60793 (/ISO) Q60843 (/ISO)
Visceral serous pericardium development GO:0061032
The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.
2 P19544 (/IGI) Q9PUT7 (/IGI)
Visceral serous pericardium development GO:0061032
The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.
2 P22561 (/IMP) Q9PUT7 (/IMP)
Motor learning GO:0061743
Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience.
2 A0MWD2 (/IDA) J7JV33 (/IDA)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 Q923V7 (/IEP) Q9ET58 (/IEP)
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
2 P08046 (/IDA) P08152 (/IDA)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
2 P08154 (/IEP) P19544 (/IEP)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
2 A0A1D5PEL8 (/ISS) F1NF76 (/ISS)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
2 P08154 (/IEP) Q00911 (/IEP)
Cellular response to cycloheximide GO:0071409
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes.
2 Q923V7 (/IEP) Q9ET58 (/IEP)
Cellular response to laminar fluid shear stress GO:0071499
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers.
2 Q60793 (/ISO) Q60843 (/ISO)
Glomus development GO:0072013
The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment.
2 B7ZSG3 (/IMP) P79958 (/IMP)
Metanephric epithelium development GO:0072207
The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
2 A0A1D5PEL8 (/ISS) F1NF76 (/ISS)
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
1 Q8MR37 (/IMP)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
1 Q60843 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q1LXI7 (/IGI)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q9Z0Z7 (/IMP)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 P22561 (/IMP)
Metanephros development GO:0001656
The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
1 P22561 (/IMP)
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
1 P22561 (/IMP)
Branching involved in ureteric bud morphogenesis GO:0001658
The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
1 P19544 (/IGI)
Branching involved in ureteric bud morphogenesis GO:0001658
The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
1 P22561 (/IMP)
Branching involved in ureteric bud morphogenesis GO:0001658
The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
1 P22561 (/ISO)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P08046 (/IMP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 P19544 (/IGI)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 P22561 (/IMP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 P22561 (/ISO)
Mesonephros development GO:0001823
The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.
1 P22561 (/IMP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 P46099 (/IMP)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 Q06889 (/IMP)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 P43300 (/ISO)
Response to amphetamine GO:0001975
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
1 P08154 (/IEP)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
1 Q06889 (/IDA)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
1 P43300 (/ISO)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
1 P08154 (/IDA)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
1 P08046 (/IMP)
Regulation of animal organ formation GO:0003156
Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.
1 P22561 (/IMP)
Atrioventricular valve development GO:0003171
The progression of the atrioventricular valve over time, from its formation to the mature structure.
1 Q1LXI7 (/IMP)
Atrioventricular valve morphogenesis GO:0003181
The process in which the structure of the atrioventricular valve is generated and organized.
1 Q1LXI7 (/IMP)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 P46099 (/IDA)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 Q60793 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P46099 (/ISO)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 P08046 (/ISO)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 P11161 (/ISS)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 Q13887 (/TAS)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
1 P08152 (/IDA)
Nitric oxide biosynthetic process GO:0006809
The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
1 Q1LXI7 (/IMP)
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
1 Q9VZN4 (/IMP)
Neuromuscular synaptic transmission GO:0007274
The process of communication from a neuron to a muscle, across a synapse.
1 P43300 (/IMP)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
1 P57682 (/TAS)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 P22561 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P22561 (/IMP)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
1 P22561 (/IMP)
Thorax and anterior abdomen determination GO:0007356
Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.
1 P22561 (/IMP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
1 Q99JB0 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q99JB0 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P11161 (/TAS)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
1 P43300 (/IMP)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
1 P11161 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P19544 (/IGI)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P22561 (/IMP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P22561 (/ISO)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q06889 (/TAS)
Sex determination GO:0007530
Any process that establishes and transmits the specification of sexual status of an individual organism.
1 P19544 (/IDA)
Sex determination GO:0007530
Any process that establishes and transmits the specification of sexual status of an individual organism.
1 P22561 (/IMP)
Sex determination GO:0007530
Any process that establishes and transmits the specification of sexual status of an individual organism.
1 P22561 (/ISO)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 P08154 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
1 P08154 (/IMP)
Rhythmic behavior GO:0007622
The specific behavior of an organism that recur with measured regularity.
1 P08152 (/IDA)
Rhythmic behavior GO:0007622
The specific behavior of an organism that recur with measured regularity.
1 P08152 (/IMP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 P08154 (/IEP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q06889 (/TAS)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 P08152 (/IGI)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q05215 (/TAS)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P22561 (/ISO)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
1 P22561 (/IDA)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
1 P22561 (/IMP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
1 P19544 (/IEP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
1 P22561 (/IGI)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
1 P22561 (/IMP)
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
1 O42223 (/NAS)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P08046 (/IDA)
Tissue development GO:0009888
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
1 P22561 (/IMP)
Epidermal cell differentiation GO:0009913
The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.
1 Q60793 (/IMP)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 Q60793 (/IDA)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P22561 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P08154 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q60793 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9DFS2 (/IGI)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9DFS2 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q60793 (/ISO)
Positive regulation of cell death GO:0010942
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 P08154 (/IMP)
Schwann cell differentiation GO:0014037
The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
1 P08152 (/IMP)
Negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 Q923V7 (/IMP)
Negative regulation of muscle hyperplasia GO:0014740
Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia.
1 Q923V7 (/IMP)
Positive regulation of smooth muscle cell migration GO:0014911
Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
1 P08154 (/IMP)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
1 P19544 (/IDA)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
1 P22561 (/ISO)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
1 Q60793 (/IDA)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 A0S0R1 (/IMP)
Rhombomere 3 development GO:0021569
The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
1 P08152 (/IGI)
Hindbrain morphogenesis GO:0021575
The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
1 Q05159 (/IMP)
Facial nerve structural organization GO:0021612
The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
1 P08152 (/IGI)
Optic nerve formation GO:0021634
The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
1 Q5TYN4 (/IDA)
Rhombomere boundary formation GO:0021654
The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
1 Q05159 (/IMP)
Rhombomere 3 formation GO:0021660
The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
1 P08152 (/IMP)
Rhombomere 5 formation GO:0021666
The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.
1 P08152 (/IMP)
Cerebellar Purkinje cell differentiation GO:0021702
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.
1 A0S0R1 (/IMP)
Cerebellar granule cell differentiation GO:0021707
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
1 A0S0R1 (/IMP)
Microvillus assembly GO:0030033
Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.
1 Q9Z0Z7 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q9DFS2 (/IMP)
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
1 Q9DFS2 (/IGI)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 Q60793 (/IMP)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
1 B7ZSG3 (/IGI)
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
1 Q99612 (/NAS)
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
1 P08046 (/IMP)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
1 P46099 (/ISO)
Regulation of ossification GO:0030278
Any process that modulates the frequency, rate or extent of bone formation.
1 P08152 (/IMP)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 P19544 (/IDA)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 P22561 (/ISO)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 P22561 (/IMP)
Adrenal gland development GO:0030325
The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
1 P22561 (/ISO)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q60793 (/IMP)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P08046 (/IDA)
Male genitalia development GO:0030539
The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.
1 P22561 (/IMP)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
1 P22561 (/IMP)
Post-embryonic camera-type eye development GO:0031077
The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure.
1 Q60793 (/IMP)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 P08154 (/IEP)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 Q60793 (/ISO)
Positive regulation of cellular protein metabolic process GO:0032270
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
1 Q60793 (/ISO)
Response to follicle-stimulating hormone GO:0032354
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.
1 P08154 (/IEP)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 Q60793 (/IDA)
Regulation of microvillus assembly GO:0032534
A process that modulates the formation of a microvillus.
1 Q9Z0Z7 (/IMP)
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
1 Q9ET58 (/IMP)
Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
1 P19544 (/IGI)
Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
1 P22561 (/ISO)
Glomerular basement membrane development GO:0032836
The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.
1 P19544 (/IMP)
Glomerular basement membrane development GO:0032836
The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.
1 P22561 (/ISO)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P08046 (/IDA)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P51774 (/IMP)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P08154 (/IEP)
Positive regulation of T cell differentiation in thymus GO:0033089
Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.
1 P43300 (/IMP)
Regulation of protein sumoylation GO:0033233
Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein.
1 P18146 (/IDA)
Regulation of protein sumoylation GO:0033233
Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein.
1 P08046 (/ISO)
Erythrocyte homeostasis GO:0034101
Any process of regulating the production and elimination of erythrocytes within an organism.
1 Q60843 (/IMP)
Negative regulation of heterotypic cell-cell adhesion GO:0034115
Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion.
1 Q60793 (/ISO)
Response to carbon monoxide GO:0034465
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus.
1 P08154 (/IEP)
Response to laminar fluid shear stress GO:0034616
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls.
1 Q9ET58 (/IEP)
Response to gonadotropin GO:0034698
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
1 P08154 (/IEP)
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
1 P46099 (/IMP)
Post-embryonic hemopoiesis GO:0035166
The stages of blood cell formation that take place after completion of embryonic development.
1 Q60793 (/ISO)
Preblastoderm mitotic cell cycle GO:0035185
The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis.
1 Q8MR37 (/IMP)
Hatching GO:0035188
The emergence of an immature organism from a protective structure.
1 Q9DFS2 (/IMP)
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
1 Q60843 (/IMP)
Brain segmentation GO:0035284
Division of the brain into a series of semi-repetitive parts or segments.
1 P08152 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P08154 (/IEP)
Endothelial cell chemotaxis GO:0035767
The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q06889 (/IMP)
Endothelial cell chemotaxis GO:0035767
The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 P43300 (/ISO)
Adrenal cortex formation GO:0035802
The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate).
1 P22561 (/IMP)
Cellular response to vascular endothelial growth factor stimulus GO:0035924
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
1 Q06889 (/IMP)
Cellular response to vascular endothelial growth factor stimulus GO:0035924
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
1 P43300 (/ISO)
Positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
1 Q9Y5W3 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
1 Q60843 (/ISO)
Specification of pronephric proximal tubule identity GO:0039004
The process in which the proximal tubule of the pronephric nephron acquires its identity.
1 B7ZSG3 (/IMP)
Pronephric glomerulus development GO:0039021
The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.
1 Q9PUT7 (/IGI)
Pronephric glomerulus development GO:0039021
The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.
1 Q9PUT7 (/IMP)
Pronephric duct development GO:0039022
The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney.
1 Q9PUT7 (/IGI)
Regulation of gene expression, epigenetic GO:0040029
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
1 Q60843 (/IGI)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 P08154 (/IEP)
Regulation of cell proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 Q60793 (/IGI)
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
1 P08154 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P08154 (/IEP)
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
1 P08152 (/IMP)
Negative regulation of mesodermal cell fate specification GO:0042662
Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.
1 Q1LXI7 (/IGI)
Regulation of ectodermal cell fate specification GO:0042665
Any process that mediates the specification of a cell into an ectoderm cell.
1 Q1LXI7 (/IGI)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 P08046 (/IMP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
1 Q9I8A0 (/IEP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P19544 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P22561 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P19544 (/IGI)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
1 Q60793 (/ISO)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
1 Q9TZ64 (/IMP)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
1 Q18250 (/IMP)
Negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q60793 (/IMP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
1 P08154 (/IMP)
Cellular lipid metabolic process GO:0044255
The chemical reactions and pathways involving lipids, as carried out by individual cells.
1 Q9TZ64 (/IMP)
Cellular response to fibroblast growth factor stimulus GO:0044344
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
1 Q06889 (/IMP)
Cellular response to fibroblast growth factor stimulus GO:0044344
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
1 P43300 (/ISO)
Estrous cycle GO:0044849
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
1 P08046 (/IMP)
Positive regulation of chemokine biosynthetic process GO:0045080
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.
1 P08046 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q65ZG6 (/IEP)
Negative regulation of interleukin-8 biosynthetic process GO:0045415
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.
1 Q60793 (/ISO)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q9Y5W3 (/IDA)
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
1 P11161 (/ISS)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P08154 (/IEP)
Regulation of gamma-delta T cell differentiation GO:0045586
Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation.
1 P43300 (/IDA)
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
1 Q60793 (/IDA)
Negative regulation of cell differentiation GO:0045596
Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
1 Q9I8A0 (/NAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q923V7 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q60793 (/NAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P19544 (/IGI)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q99612 (/TAS)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P08154 (/IC)
Positive regulation of hormone biosynthetic process GO:0046886
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.
1 P08046 (/IMP)
Positive regulation of hemoglobin biosynthetic process GO:0046985
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
1 Q60793 (/ISO)
Regulation of neuronal synaptic plasticity GO:0048168
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
1 P51774 (/IEP)
Regulation of long-term neuronal synaptic plasticity GO:0048169
A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
1 P08154 (/IMP)
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
1 E9QG09 (/IMP)
Embryonic organ development GO:0048568
Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q05159 (/IMP)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 P08154 (/IMP)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
1 Q923V7 (/IDA)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
1 Q923V7 (/IMP)
Regulation of axon regeneration GO:0048679
Any process that modulates the frequency, rate or extent of axon regeneration.
1 Q60793 (/IGI)
Regulation of axon regeneration GO:0048679
Any process that modulates the frequency, rate or extent of axon regeneration.
1 Q60793 (/IMP)
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
1 P26632 (/IMP)
Oligodendrocyte differentiation GO:0048709
The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
1 P08154 (/IEP)
Epidermis morphogenesis GO:0048730
The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
1 Q60793 (/IMP)
Hatching gland development GO:0048785
The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process.
1 Q9DFS2 (/IMP)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
1 B5DE03 (/ISS)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell.
1 Q99JB0 (/IMP)
Erythrocyte development GO:0048821
The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.
1 P46099 (/IMP)
Myelination of posterior lateral line nerve axons GO:0048932
The formation of compact myelin sheaths around the axons of the posterior lateral line nerve.
1 Q05159 (/IMP)
Positive regulation of interleukin-1 beta biosynthetic process GO:0050725
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta.
1 P08046 (/IMP)
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
1 Q9VZN4 (/IMP)
Positive regulation of protein metabolic process GO:0051247
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
1 Q9Y5W3 (/IGI)
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
1 P08154 (/IEP)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 Q923V7 (/IMP)
Positive regulation of telomerase activity GO:0051973
Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
1 Q60793 (/ISO)
Sertoli cell development GO:0060009
The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate.
1 P22561 (/IMP)
Embryonic retina morphogenesis in camera-type eye GO:0060059
The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage.
1 P26632 (/IMP)
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
1 Q60793 (/IMP)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
1 G3V6F3 (/IEP)
Mesenchymal to epithelial transition GO:0060231
A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.
1 P22561 (/IMP)
Negative regulation of ovulation GO:0060280
Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
1 Q18250 (/IMP)
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
1 P08154 (/IEP)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P18146 (/TAS)
Positive regulation of heart growth GO:0060421
Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.
1 P22561 (/IMP)
Type I pneumocyte differentiation GO:0060509
The process in which a relatively unspecialized cell acquires specialized features of a Type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.
1 Q60843 (/IMP)
Diaphragm development GO:0060539
The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.
1 P22561 (/IMP)
Intestinal epithelial cell development GO:0060576
The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.
1 Q9Z0Z7 (/IMP)
Negative regulation of response to cytokine stimulus GO:0060761
Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus.
1 Q60793 (/ISO)
Cardiac muscle cell fate commitment GO:0060923
The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 P22561 (/IMP)
Cardiac muscle cell fate commitment GO:0060923
The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 P19544 (/ISS)
Coronary vasculature development GO:0060976
The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.
1 P22561 (/TAS)
Kidney morphogenesis GO:0060993
Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.
1 Q9I8A0 (/NAS)
Visceral serous pericardium development GO:0061032
The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.
1 P22561 (/ISO)
Visceral serous pericardium development GO:0061032
The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.
1 P22561 (/TAS)
Regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
1 P08046 (/IDA)
Kidney vasculature development GO:0061440
The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure.
1 B7ZSG3 (/TAS)
Endocardial cushion cell development GO:0061444
The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state.
1 Q1LXI7 (/IMP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q923V7 (/IMP)
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P18146 (/IMP)
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P08046 (/ISO)
Cellular response to antibiotic GO:0071236
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 P08154 (/IEP)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P08154 (/IEP)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 Q923V7 (/IEP)
Cellular response to isoquinoline alkaloid GO:0071317
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids.
1 P08154 (/IEP)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q9ET58 (/IEP)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q9ET58 (/IEP)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
1 Q60793 (/ISO)
Cellular response to gonadotropin stimulus GO:0071371
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
1 P19544 (/IDA)
Cellular response to gonadotropin stimulus GO:0071371
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
1 P08154 (/IEP)
Cellular response to gonadotropin stimulus GO:0071371
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
1 P22561 (/ISO)
Cellular response to follicle-stimulating hormone stimulus GO:0071372
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.
1 P08154 (/IEP)
Cellular response to steroid hormone stimulus GO:0071383
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
1 P08154 (/IEP)
Cellular response to hyperoxia GO:0071455
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.
1 P08154 (/IEP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P08154 (/IEP)
Cellular response to gamma radiation GO:0071480
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
1 P08046 (/IMP)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
1 Q9Y5W3 (/IMP)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
1 Q60843 (/ISO)
Cellular response to laminar fluid shear stress GO:0071499
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers.
1 Q9Y5W3 (/IMP)
Cellular response to heparin GO:0071504
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.
1 P08154 (/IDA)
Cellular response to mycophenolic acid GO:0071506
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus.
1 P08154 (/IDA)
Response to norepinephrine GO:0071873
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.
1 P08154 (/IEP)
Glomus development GO:0072013
The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment.
1 B5DE03 (/ISS)
Glomerular visceral epithelial cell development GO:0072015
The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
1 P22561 (/IEP)
Metanephric mesenchyme development GO:0072075
The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros.
1 P22561 (/IMP)
Glomerular mesangial cell proliferation GO:0072110
The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population.
1 P08154 (/IMP)
Glomerular visceral epithelial cell differentiation GO:0072112
The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
1 P22561 (/IDA)
Glomerular visceral epithelial cell differentiation GO:0072112
The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
1 Q9PUT7 (/IMP)
Glomerular visceral epithelial cell fate commitment GO:0072149
The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
1 Q9PUT7 (/IGI)
Posterior mesonephric tubule development GO:0072166
The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros.
1 P22561 (/IMP)
Metanephric epithelium development GO:0072207
The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
1 P19544 (/IEP)
Metanephric comma-shaped body morphogenesis GO:0072278
The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros.
1 P22561 (/IEP)
Metanephric S-shaped body morphogenesis GO:0072284
The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.
1 P22561 (/IEP)
Metanephric S-shaped body morphogenesis GO:0072284
The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.
1 P19544 (/IGI)
Metanephric S-shaped body morphogenesis GO:0072284
The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.
1 P22561 (/IMP)
Metanephric S-shaped body morphogenesis GO:0072284
The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.
1 P22561 (/ISO)
Negative regulation of metanephric glomerular mesangial cell proliferation GO:0072302
Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.
1 P22561 (/IMP)
Positive regulation of glomerular metanephric mesangial cell proliferation GO:0072303
Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.
1 P08154 (/IMP)
Seminiferous tubule development GO:0072520
The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa.
1 P22561 (/IMP)
Negative regulation of cell migration involved in sprouting angiogenesis GO:0090051
Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
1 Q60793 (/ISO)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 P08046 (/IMP)
Cellular response to interleukin-8 GO:0098759
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus.
1 P18146 (/IDA)
Cellular response to interleukin-8 GO:0098759
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus.
1 P08046 (/ISO)
Negative regulation of oocyte maturation GO:1900194
Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.
1 Q18250 (/IMP)
Negative regulation of pronephric nephron tubule development GO:1900207
Any process that stops, prevents or reduces the frequency, rate or extent of pronephric nephron tubule development.
1 B7ZSG3 (/IMP)
Negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212
Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development.
1 P22561 (/IMP)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 A0A0H2UHR3 (/IGI)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 P18146 (/ISS)
Positive regulation of tau-protein kinase activity GO:1902949
Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity.
1 A0A0H2UHR3 (/IGI)
Positive regulation of tau-protein kinase activity GO:1902949
Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity.
1 P18146 (/ISS)
Regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903025
Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
1 Q8VCZ7 (/IDA)
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
1 Q9VZN4 (/IMP)
Positive regulation of core promoter binding GO:1904798
Any process that activates or increases the frequency, rate or extent of core promoter binding.
1 Q60793 (/IMP)
Negative regulation of leukocyte adhesion to arterial endothelial cell GO:1904998
Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell.
1 Q60793 (/ISO)
Positive regulation of male gonad development GO:2000020
Any process that activates or increases the frequency, rate or extent of male gonad development.
1 P22561 (/IMP)
Regulation of progesterone biosynthetic process GO:2000182
Any process that modulates the frequency, rate or extent of progesterone biosynthetic process.
1 P08046 (/IMP)
Negative regulation of female gonad development GO:2000195
Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.
1 P22561 (/IMP)
Negative regulation of chemokine (C-X-C motif) ligand 2 production GO:2000342
Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production.
1 Q60793 (/ISO)
Negative regulation of peptidyl-lysine acetylation GO:2000757
Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation.
1 Q9UIH9 (/IMP)
Positive regulation of metanephric ureteric bud development GO:2001076
Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development.
1 P22561 (/IMP)

There are 40 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
25 A0A1D5PEL8 (/ISS) A1XSY8 (/ISS) A4II20 (/ISS) B8QHP7 (/ISS) F1NF76 (/ISS) O62651 (/ISS) O73691 (/ISS) O73692 (/ISS) O73693 (/ISS) O73694 (/ISS)
(15 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
23 A0A1D5PEL8 (/ISS) A1XSY8 (/ISS) A4II20 (/ISS) B8QHP7 (/ISS) F1NF76 (/ISS) O62651 (/ISS) O73691 (/ISS) O73692 (/ISS) O73693 (/ISS) O73694 (/ISS)
(13 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
18 P08046 (/IDA) P08152 (/IDA) P08154 (/IDA) P18146 (/IDA) P19544 (/IDA) P22561 (/IDA) P49952 (/IDA) Q13351 (/IDA) Q18250 (/IDA) Q60793 (/IDA)
(8 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
15 A0A024R9T8 (/IDA) A0A024R9X4 (/IDA) A0A0A0MT54 (/IDA) H0Y7K5 (/IDA) H0YED9 (/IDA) J3KNN9 (/IDA) O95600 (/IDA) P11161 (/IDA) P18146 (/IDA) P19544 (/IDA)
(5 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 A0A024R9X4 (/IDA) A0A0A0MT54 (/IDA) H0Y7K5 (/IDA) H0YED9 (/IDA) J3KNN9 (/IDA) O95600 (/IDA) P19544 (/IDA) Q99612 (/IDA) Q9Y4X4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA) Q9I8A0 (/ISA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
8 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA) Q9I8A0 (/ISA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
8 O35738 (/ISO) P08046 (/ISO) P08152 (/ISO) P22561 (/ISO) Q60793 (/ISO) Q60980 (/ISO) Q8BLM0 (/ISO) Q9Z0Z7 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) O73691 (/ISA) O73692 (/ISA) O73693 (/ISA) O73694 (/ISA) Q9I8A0 (/ISA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P22561 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
7 A0A1D5PEL8 (/ISS) F1NF76 (/ISS) O62651 (/ISS) P22561 (/ISS) P49952 (/ISS) P49953 (/ISS) P50902 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P08152 (/IDA) P08154 (/IDA) P18146 (/IDA) P22561 (/IDA) Q60793 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
4 A9CSE6 (/ISA) A9CSE8 (/ISA) O42223 (/ISA) Q9I8A0 (/ISA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
4 P11161 (/IDA) Q13887 (/IDA) Q5T6X2 (/IDA) Q99612 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
3 P46099 (/ISO) Q60793 (/ISO) Q60843 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P08152 (/IC) P11161 (/IC) Q9DFS2 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P08046 (/ISO) P22561 (/ISO) P46099 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 P08152 (/TAS) P18146 (/TAS) Q9Z0Z7 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O35738 (/ISO) P22561 (/ISO) Q8BLM0 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P51774 (/TAS) Q99612 (/TAS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 Q13887 (/IDA) Q5T6X2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 A0A1D5PEL8 (/ISS) F1NF76 (/ISS)
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
2 A0A024R9X4 (/IDA) O95600 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 P08152 (/ISO) Q9Z0Z7 (/ISO)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 Q923V7 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q13351 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q9Y5W3 (/IMP)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
1 Q99612 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q60793 (/NAS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 Q923V7 (/IDA)
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
1 Q60793 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q99612 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P08046 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q9Z0Z7 (/ISO)
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
1 Q8BLM0 (/ISO)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 P19544 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 P22561 (/ISO)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 P22561 (/TAS)
Nuclear transcription factor complex GO:0044798
A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 Q60793 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q18250 (/IDA)