The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Classic Zinc Finger
".
FunFam 23337: Recombination activating gene 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endonuclease activity GO:0004519
Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P15918 (/IPI) P15919 (/IPI) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | P15918 (/TAS) |
|
Endonuclease activity GO:0004519
Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
|
1 | P15919 (/IMP) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | P15919 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | P15919 (/IDA) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | P15919 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P15919 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | P15919 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | P15919 (/IMP) |
|
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
|
1 | P15919 (/IMP) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | P15919 (/IDA) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | P15919 (/ISO) |
There are 25 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
T cell differentiation in thymus GO:0033077
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
V(D)J recombination GO:0033151
The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
Pre-B cell allelic exclusion GO:0002331
Expression of a single heavy chain allele during pre-B cell differentiation.
|
3 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
3 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) |
|
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
|
2 | P15918 (/TAS) P15919 (/TAS) |
|
V(D)J recombination GO:0033151
The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
|
2 | P15918 (/IMP) P15919 (/IMP) |
|
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
|
1 | P15919 (/IMP) |
|
Pre-B cell allelic exclusion GO:0002331
Expression of a single heavy chain allele during pre-B cell differentiation.
|
1 | P15919 (/IMP) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
1 | P15918 (/TAS) |
|
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
1 | P15919 (/IDA) |
|
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
|
1 | P15919 (/IDA) |
|
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
|
1 | P15919 (/IMP) |
|
T cell differentiation in thymus GO:0033077
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
|
1 | P15919 (/IMP) |
|
V(D)J recombination GO:0033151
The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
|
1 | P15919 (/IGI) |
|
V(D)J recombination GO:0033151
The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
|
1 | P15919 (/ISO) |
|
T cell homeostasis GO:0043029
The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
1 | P15919 (/IGI) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
1 | P15919 (/IMP) |
|
Regulation of T cell differentiation GO:0045580
Any process that modulates the frequency, rate or extent of T cell differentiation.
|
1 | P15919 (/IGI) |
|
Positive regulation of T cell differentiation GO:0045582
Any process that activates or increases the frequency, rate or extent of T cell differentiation.
|
1 | P15919 (/IMP) |
|
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
|
1 | P15919 (/IGI) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | P15919 (/IDA) |
|
Negative regulation of T cell apoptotic process GO:0070233
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.
|
1 | P15919 (/IGI) |
|
Negative regulation of thymocyte apoptotic process GO:0070244
Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process.
|
1 | P15919 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | P15918 (/ISS) P34088 (/ISS) Q867B5 (/ISS) Q91829 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P15918 (/TAS) P15919 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P15919 (/IDA) |