The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6940: Dicer-2, isoform A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
2 A0A0B4LFK8 (/ISS) A1ZAW0 (/ISS)
Helicase activity GO:0004386
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.
2 A0A0B4LFK8 (/ISS) A1ZAW0 (/ISS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
2 A0A0B4LFK8 (/IDA) A1ZAW0 (/IDA)
SiRNA binding GO:0035197
Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.
2 A0A0B4LFK8 (/IDA) A1ZAW0 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 A1ZAW0 (/IPI)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
MRNA cleavage GO:0006379
Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
Dosage compensation by hyperactivation of X chromosome GO:0009047
Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster.
2 A0A0B4LFK8 (/IGI) A1ZAW0 (/IGI)
Detection of virus GO:0009597
The series of events in which a stimulus from a virus is received and converted into a molecular signal.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
RNA interference GO:0016246
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
2 A0A0B4LFK8 (/IDA) A1ZAW0 (/IDA)
RNA interference GO:0016246
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
Production of siRNA involved in RNA interference GO:0030422
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
2 A0A0B4LFK8 (/IDA) A1ZAW0 (/IDA)
Production of siRNA involved in RNA interference GO:0030422
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
Production of siRNA involved in RNA interference GO:0030422
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
2 A0A0B4LFK8 (/TAS) A1ZAW0 (/TAS)
Targeting of mRNA for destruction involved in RNA interference GO:0030423
The process in which small interfering RNAs target cognate mRNA molecules for degradation.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
DsRNA transport GO:0033227
The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
SiRNA loading onto RISC involved in RNA interference GO:0035087
The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
Heterochromatin organization involved in chromatin silencing GO:0070868
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)
Cellular response to virus GO:0098586
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 A0A0B4LFK8 (/IMP) A1ZAW0 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 A0A0B4LFK8 (/IDA) A1ZAW0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 A0A0B4LFK8 (/IDA) A1ZAW0 (/IDA)
RISC complex GO:0016442
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
2 A0A0B4LFK8 (/IDA) A1ZAW0 (/IDA)