The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
ATP-grasp fold, A domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6221: Bifunctional glutamate--cysteine ligase/glutathion...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutathione synthase. [EC: 6.3.2.3]
ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.
    8 A0A0P7I345 A0A165RBM5 A0A1A0DIL1 A0A1L5S275 D7VFX8 M4KMY2 Q88UW5 R9X4H9
    Glutamate--cysteine ligase. [EC: 6.3.2.2]
    ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L- cysteine.
    • Can use L-aminohexanoate in place of glutamate.
    7 A0A0P7I345 A0A165RBM5 A0A1A0DIL1 A0A1L5S275 M4KMY2 Q88UW5 R9X4H9