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CATH Superfamily 3.30.1490.20

ATP-grasp fold, A domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
ATP-grasp fold, A domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23037: Putative D-alanine--D-lactate ligase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
D-alanine--D-alanine ligase. [EC: 6.3.2.4]
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
  • Involved with EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.
 267 A0A022SVP7 A0A059N5H7 A0A060RFP6 A0A066TMA5 A0A075FA30 A0A075V242 A0A076M1N0 A0A090ZCC9 A0A093B4D6 A0A094JKX4
(257 more...)
D-alanine--(R)-lactate ligase. [EC: 6.1.2.1]
D-alanine + (R)-lactate + ATP = D-alanyl-(R)-lactate + ADP + phosphate.
  • The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4.
  • The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
 11 A0A059N5H7 A0A0M1XWY7 C7WYV3 D4RFM1 F8WTX8 P25051 Q06893 Q0WYK7 Q7B608 Q7BWD7
(1 more...)