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CATH Superfamily 3.30.1490.180

RNA polymerase ii

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
RNA polymerase ii
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 771: DNA-directed RNA polymerase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA-directed RNA polymerase. [EC: 2.7.7.6]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
  • Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
  • Can initiate a chain de novo.
  • In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized.
  • See also EC 2.7.7.19 and EC 2.7.7.48.
 133 A0A024RV95 A0A061HE74 A0A063BLU6 A0A066X9I1 A0A084AFR0 A0A084QEI0 A0A084RBT9 A0A086TBR4 A0A093YJN7 A0A093Z376
(123 more...)
Shikimate kinase. [EC: 2.7.1.71]
ATP + shikimate = ADP + shikimate 3-phosphate.
    		 2 A0A093ZYW5 A0A094CHT8
    3-dehydroquinate synthase. [EC: 4.2.3.4]
    3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.
    • The hydrogen atoms on C-7 of the substrate are retained on C-2 of the products.
    • Formerly EC 4.6.1.3.
    		 2 A0A093ZYW5 A0A094CHT8
    3-phosphoshikimate 1-carboxyvinyltransferase. [EC: 2.5.1.19]
    Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O- (1-carboxyvinyl)-3-phosphoshikimate.
      		 2 A0A093ZYW5 A0A094CHT8
      Shikimate dehydrogenase. [EC: 1.1.1.25]
      Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
      • NAD(+) cannot replace NADP(+).
      • In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.
      		 2 A0A093ZYW5 A0A094CHT8
      3-dehydroquinate dehydratase. [EC: 4.2.1.10]
      3-dehydroquinate = 3-dehydroshikimate + H(2)O.
        		 2 A0A093ZYW5 A0A094CHT8
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