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CATH Superfamily 3.30.1380.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 744: D-alanyl-D-alanine dipeptidase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
D-Ala-D-Ala dipeptidase. [EC: 3.4.13.22]
D-Ala-D-Ala + H(2)O = 2 D-Ala.
  • Protects Enterococcus faecium from the antibiotic vancomycin, which can bind to the -D-Ala-D-Ala sequence at the C-terminus of the peptidoglycan pentapeptide.
  • Reduces the availability of the free dipeptide D-Ala-D-Ala, which is the precursor for this pentapeptide sequence, allowing D-Ala-(R)- lactate (for which vancomycin has much less affinity) to be added to the cell wall instead.
  • The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala- D-Ala are not substrates.
  • Belongs to peptidase family M15.
 210 A0A023YX28 A0A024KVG7 A0A025C806 A0A026V6I6 A0A027TGP1 A0A027ZGI4 A0A028E0S0 A0A029KVV5 A0A029LP59 A0A029PNH4
(200 more...)