The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
K Homology domain, type 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8683: Far upstream element-binding protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 Q91WJ8 (/IPI) Q91WJ8 (/IPI) Q92945 (/IPI) Q92945 (/IPI) Q96AE4 (/IPI) Q96AE4 (/IPI) Q96I24 (/IPI) Q96I24 (/IPI) Q99PF5 (/IPI) Q99PF5 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
9 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO) Q3U0V1 (/ISO) Q3U0V1 (/ISO) Q91WJ8 (/ISO) Q91WJ8 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
6 Q92945 (/IDA) Q92945 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96I24 (/IDA) Q96I24 (/IDA)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
6 Q3U0V1 (/ISS) Q3U0V1 (/ISS) Q8UVD9 (/ISS) Q8UVD9 (/ISS) Q99PF5 (/ISS) Q99PF5 (/ISS)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
5 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
5 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
5 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
4 Q8UVD9 (/IDA) Q8UVD9 (/IDA) Q99PF5 (/IDA) Q99PF5 (/IDA)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
2 Q96I24 (/IDA) Q96I24 (/IDA)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
2 Q96I24 (/IDA) Q96I24 (/IDA)
Transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001205
Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
2 Q91WJ8 (/IDA) Q91WJ8 (/IDA)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
2 Q96AE4 (/TAS) Q96AE4 (/TAS)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
2 Q96AE4 (/TAS) Q96AE4 (/TAS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 Q3U0V1 (/IDA) Q3U0V1 (/IDA)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
2 Q92945 (/IDA) Q92945 (/IDA)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
2 Q3U0V1 (/ISO) Q3U0V1 (/ISO)

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
7 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO) Q91WJ8 (/ISO) Q91WJ8 (/ISO)
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
6 Q3U0V1 (/ISS) Q3U0V1 (/ISS) Q8UVD9 (/ISS) Q8UVD9 (/ISS) Q99PF5 (/ISS) Q99PF5 (/ISS)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
6 Q3U0V1 (/ISS) Q3U0V1 (/ISS) Q8UVD9 (/ISS) Q8UVD9 (/ISS) Q99PF5 (/ISS) Q99PF5 (/ISS)
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
6 Q3U0V1 (/ISS) Q3U0V1 (/ISS) Q8UVD9 (/ISS) Q8UVD9 (/ISS) Q99PF5 (/ISS) Q99PF5 (/ISS)
Positive regulation of mRNA catabolic process GO:0061014
Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
6 Q3U0V1 (/ISS) Q3U0V1 (/ISS) Q8UVD9 (/ISS) Q8UVD9 (/ISS) Q99PF5 (/ISS) Q99PF5 (/ISS)
3'-UTR-mediated mRNA destabilization GO:0061158
An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
6 Q3U0V1 (/ISS) Q3U0V1 (/ISS) Q8UVD9 (/ISS) Q8UVD9 (/ISS) Q99PF5 (/ISS) Q99PF5 (/ISS)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
6 Q3U0V1 (/ISS) Q3U0V1 (/ISS) Q8UVD9 (/ISS) Q8UVD9 (/ISS) Q99PF5 (/ISS) Q99PF5 (/ISS)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
5 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
5 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 Q96AE4 (/IDA) Q96AE4 (/IDA) Q96I24 (/IDA) Q96I24 (/IDA)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
4 Q3U0V1 (/TAS) Q3U0V1 (/TAS) Q92945 (/TAS) Q92945 (/TAS)
RNA splicing, via transesterification reactions GO:0000375
Splicing of RNA via a series of two transesterification reactions.
2 Q92945 (/TAS) Q92945 (/TAS)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
2 Q96I24 (/IDA) Q96I24 (/IDA)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q91WJ8 (/IMP) Q91WJ8 (/IMP)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
2 Q96AE4 (/TAS) Q96AE4 (/TAS)
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
2 Q92945 (/TAS) Q92945 (/TAS)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
2 Q3U0V1 (/IDA) Q3U0V1 (/IDA)
Intracellular mRNA localization GO:0008298
Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
2 Q8UVD9 (/NAS) Q8UVD9 (/NAS)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
2 Q92945 (/TAS) Q92945 (/TAS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q6P2A9 (/IGI) Q6P2A9 (/IGI)
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
2 Q92945 (/IMP) Q92945 (/IMP)
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
2 Q3U0V1 (/ISO) Q3U0V1 (/ISO)
Cell growth GO:0016049
The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
2 Q91WJ8 (/IMP) Q91WJ8 (/IMP)
Stem cell division GO:0017145
The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.
2 Q91WJ8 (/IMP) Q91WJ8 (/IMP)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
2 Q92945 (/IDA) Q92945 (/IDA)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
2 Q3U0V1 (/ISO) Q3U0V1 (/ISO)
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
2 Q92945 (/IDA) Q92945 (/IDA)
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
2 Q3U0V1 (/ISO) Q3U0V1 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q96I24 (/IDA) Q96I24 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q96I24 (/IDA) Q96I24 (/IDA)
Positive regulation of mRNA catabolic process GO:0061014
Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
2 Q92945 (/IDA) Q92945 (/IDA)
Positive regulation of mRNA catabolic process GO:0061014
Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
2 Q3U0V1 (/ISO) Q3U0V1 (/ISO)
3'-UTR-mediated mRNA destabilization GO:0061158
An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
2 Q92945 (/IDA) Q92945 (/IDA)
3'-UTR-mediated mRNA destabilization GO:0061158
An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
2 Q3U0V1 (/ISO) Q3U0V1 (/ISO)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
2 Q92945 (/IMP) Q92945 (/IMP)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
2 Q3U0V1 (/ISO) Q3U0V1 (/ISO)
Hematopoietic stem cell proliferation GO:0071425
The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.
2 Q91WJ8 (/IMP) Q91WJ8 (/IMP)
Regulation of miRNA metabolic process GO:2000628
Any process that modulates the frequency, rate or extent of miRNA metabolic process.
2 Q3U0V1 (/IDA) Q3U0V1 (/IDA)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 Q8UVD9 (/IDA) Q8UVD9 (/IDA) Q96AE4 (/IDA) Q96AE4 (/IDA) Q96I24 (/IDA) Q96I24 (/IDA) Q99PF5 (/IDA) Q99PF5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO) Q91WJ8 (/ISO) Q91WJ8 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
7 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO) Q3U0V1 (/ISO) Q3U0V1 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 A0A087WTP3 (/IDA) A0A087WTP3 (/IDA) M0QYH3 (/IDA) M0R0I5 (/IDA) Q92945 (/IDA) Q92945 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 A0A0A6YVV5 (/ISO) A2AJ72 (/ISO) A2AJ72 (/ISO) Q3TIX6 (/ISO) Q3TIX6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q8UVD9 (/IDA) Q8UVD9 (/IDA) Q96I24 (/IDA) Q96I24 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q3U0V1 (/TAS) Q3U0V1 (/TAS) Q92945 (/TAS) Q92945 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 Q92945 (/IDA) Q92945 (/IDA) Q96I24 (/IDA) Q96I24 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q96I24 (/NAS) Q96I24 (/NAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q3U0V1 (/ISO) Q3U0V1 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q92945 (/TAS) Q92945 (/TAS)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
2 Q3U0V1 (/IDA) Q3U0V1 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q99PF5 (/IDA) Q99PF5 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q99PF5 (/IDA) Q99PF5 (/IDA)
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