View in Gene3D

CATH Superfamily 3.30.1360.30

GAD-like domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
GAD-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2171: Aspartate--tRNA ligase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aspartate--tRNA ligase. [EC: 6.1.1.12]
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
    		 1521 A0A009H8J9 A0A009HFA4 A0A009RCX7 A0A010Q2Z5 A0A011MWA8 A0A011N7K3 A0A011NL55 A0A011NWF1 A0A011QTT1 A0A022PN14
    (1511 more...)
    Aspartate--tRNA(Asn) ligase. [EC: 6.1.1.23]
    ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx).
    • When this enzyme acts on tRNA(Asp), it catalyzes the same reaction as EC 6.1.1.12.
    • It has, however, diminished discrimination, so that it can also form aspartyl-tRNA(Asn).
    • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
    • This accounts for the ability of this enzyme in, for example, Thermus thermophilus, to recognize both tRNA(Asp) (GUC anticodon) and tRNA(Asn) (GUU anticodon).
    • The aspartate-tRNA(Asn) is not used in protein synthesis until it is converted by EC 6.3.5.6 into asparaginyl-tRNA(Asn).
    		 321 A0A009H8J9 A0A009HFA4 A0A009ISE8 A0A009KY02 A0A009RCX7 A0A009TH29 A0A059ZUI9 A0A062DG01 A0A062F1L4 A0A062FC75
    (311 more...)