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CATH Superfamily 3.30.1330.90

D-3-phosphoglycerate dehydrogenase; domain 3

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
D-3-phosphoglycerate dehydrogenase; domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1783: D-3-phosphoglycerate dehydrogenase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphoglycerate dehydrogenase. [EC: 1.1.1.95]
3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + NADH.
  • Catalyzes the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis.
  • The reaction occurs predominantly in the direction of reduction.
  • The enzyme from the bacterium Escherichia coli also catalyzes the activity of EC 1.1.1.399.
 45 A0A096N8I8 A0A0D9S621 A0A0P6CDW1 A0A140T866 A0A158SIP3 A5A6P1 A5GFY8 D2HZW5 F6YJM1 F7DRL6
(35 more...)
2-oxoglutarate reductase. [EC: 1.1.1.399]
(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH.
  • The enzyme catalyzes a reversible reaction.
  • The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate.
  • The SerA enzyme from Escherichia coli can also accept (S)-2- hydroxyglutarate with a much higher Km, and also catalyzes the activity of EC 1.1.1.95.
 8 A0A158SIP3 A5A6P1 A5GFY8 H9FST6 O43175 Q5EAD2 Q5R7M2 Q60HD7
Malate dehydrogenase. [EC: 1.1.1.37]
(S)-malate + NAD(+) = oxaloacetate + NADH.
  • Also oxidizes some other 2-hydroxydicarboxylic acids.
 8 A0A158SIP3 A5A6P1 A5GFY8 H9FST6 O43175 Q5EAD2 Q5R7M2 Q60HD7