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CATH Superfamily 3.30.1330.30

Ribosomal protein L30/S12

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6984: rRNA methyltransferase 3, mitochondrial

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA (guanosine(18)-2'-O)-methyltransferase. [EC: 2.1.1.34]
S-adenosyl-L-methionine + guanosine(18) in tRNA = S-adenosyl-L- homocysteine + 2'-O-methylguanosine(18) in tRNA.
  • The enzyme catalyzes the methylation of guanosine(18) in tRNA.
 17 A0A045H1D1 A0A083W934 A0A0G4E1M3 A0A0H3L8Z6 A0A0H3M5B7 A0A0H3P890 A0A0K2HVW1 A0A0T9ERF8 A0A0U0SN95 A0A120IWQ7
(7 more...)
23S rRNA (uridine(2479)-2'-O)-methyltransferase. [EC: 2.1.1.208]
S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = S-adenosyl-L- homocysteine + 2'-O-methyluridine(2479) in 23S rRNA.
  • Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.
  • To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine(2479)-2'-O)- methyltransferase and EC 2.1.1.209 whose actions confer avilamycin resistance to the RNA.
 2 L8PIX0 Q9F5K6