The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Tubulin/FtsZ, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2990: Tubulin alpha 1 chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 P05213 (/IPI) P09734 (/IPI) P29511 (/IPI) P32255 (/IPI) P68363 (/IPI) P68366 (/IPI) P68369 (/IPI) P68370 (/IPI) P81948 (/IPI) Q13748 (/IPI)
(3 more)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
7 P06603 (/ISS) P06604 (/ISS) P06605 (/ISS) P06606 (/ISS) P29511 (/ISS) P91910 (/ISS) Q9VED6 (/ISS)
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
3 P68363 (/TAS) Q71U36 (/TAS) Q9BQE3 (/TAS)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
2 P24633 (/IGI) P87066 (/IGI)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
1 P68363 (/IDA)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
1 P05213 (/ISO)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
1 P04689 (/IC)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
1 P05213 (/IDA)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
1 P24633 (/IMP)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
1 Q9JJZ2 (/ISA)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
1 Q4GYY5 (/TAS)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
1 P06605 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P68368 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P68370 (/IDA)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P68363 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P05213 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P68370 (/TAS)

There are 66 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Seed trichome elongation GO:0090378
The process in which a seed trichome irreversibly increases in size in one
8 A9PL14 (/IEP) A9PL15 (/IEP) A9PL16 (/IEP) A9PL17 (/IEP) A9PL18 (/IEP) A9PL19 (/IEP) A9PL20 (/IEP) A9PL21 (/IEP)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
4 P06605 (/ISS) P06606 (/ISS) P11139 (/ISS) P91910 (/ISS)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
4 P68363 (/TAS) P68370 (/TAS) Q71U36 (/TAS) Q9BQE3 (/TAS)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
4 H2L2E8 (/IMP) O18688 (/IMP) P06606 (/IMP) P34690 (/IMP)
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
3 H2L2E8 (/IGI) O18688 (/IGI) P34690 (/IGI)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
3 H2L2E8 (/IGI) O18688 (/IGI) P34690 (/IGI)
Cytoskeleton-dependent intracellular transport GO:0030705
The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
3 P68363 (/TAS) Q71U36 (/TAS) Q9BQE3 (/TAS)
Regulation of cytokinesis GO:0032465
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
3 H2L2E8 (/IGI) O18688 (/IGI) P34690 (/IGI)
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
3 P68363 (/TAS) Q71U36 (/TAS) Q9BQE3 (/TAS)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
2 P68366 (/TAS) Q71U36 (/TAS)
Nuclear division GO:0000280
The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
2 P06606 (/IMP) P24633 (/IMP)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
2 P87066 (/IMP) P91910 (/IMP)
Mitotic spindle organization GO:0007052
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
2 P04689 (/IMP) P06606 (/IMP)
Mitotic spindle assembly checkpoint GO:0007094
A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
2 P06603 (/IDA) P06604 (/IDA)
Ciliary basal body docking GO:0097711
The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.
2 P68366 (/TAS) Q71U36 (/TAS)
Nuclear migration by microtubule mediated pushing forces GO:0098863
The directed movement of the nucleus by pushing forces exerted by polymerization of backward-extending microtubules.
2 P04688 (/IDA) P04689 (/IDA)
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
1 P09734 (/IC)
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
1 P09733 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 P05213 (/IDA)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 P29511 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 Q9JJZ2 (/ISA)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 Q4GYY5 (/TAS)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 P06605 (/IMP)
Thigmotaxis GO:0001966
The directed movement of a motile cell or organism in response to touch.
1 P91910 (/IMP)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
1 P68366 (/TAS)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 P05213 (/TAS)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
1 P87066 (/IGI)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
1 P32255 (/IDA)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 P06606 (/IMP)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
1 P06606 (/IMP)
Mechanosensory behavior GO:0007638
Behavior that is dependent upon the sensation of a mechanical stimulus.
1 P91910 (/IGI)
Mechanosensory behavior GO:0007638
Behavior that is dependent upon the sensation of a mechanical stimulus.
1 P91910 (/IMP)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
1 P34690 (/IMP)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P91910 (/IMP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 P29511 (/IEP)
C-terminal protein amino acid modification GO:0018410
The alteration of the C-terminal amino acid residue in a protein.
1 P81947 (/TAS)
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
1 P06603 (/IMP)
Optic nerve formation GO:0021634
The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
1 Q6NWK7 (/IMP)
Glial cell development GO:0021782
The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
1 Q6DC49 (/IMP)
Ascospore formation GO:0030437
The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).
1 P24634 (/IMP)
Nuclear migration along microtubule GO:0030473
The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.
1 P09734 (/IC)
Nuclear migration along microtubule GO:0030473
The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.
1 P09733 (/IMP)
Cytoplasmic microtubule organization GO:0031122
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.
1 P04689 (/IMP)
Female pronucleus assembly GO:0035038
Assembly of the haploid nucleus of the unfertilized egg.
1 P06606 (/IMP)
Sperm aster formation GO:0035044
Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei.
1 P06606 (/IMP)
Pronuclear migration GO:0035046
The directed movement of the male and female pronuclei towards each other prior to their fusion.
1 P06606 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P87066 (/IMP)
Embryonic cleavage GO:0040016
The first few specialized divisions of an activated animal egg.
1 P06606 (/IMP)
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
1 Q6DC49 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q6NWK7 (/IMP)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
1 P81947 (/TAS)
Homologous chromosome segregation GO:0045143
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets.
1 P09734 (/IC)
Homologous chromosome segregation GO:0045143
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets.
1 P09733 (/IMP)
Microtubule polymerization GO:0046785
The addition of tubulin heterodimers to one or both ends of a microtubule.
1 P24633 (/IMP)
Mitochondrion distribution GO:0048311
Any process that establishes the spatial arrangement of mitochondria between and within cells.
1 P04689 (/IMP)
Detection of mechanical stimulus involved in sensory perception of touch GO:0050976
The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal.
1 P91910 (/IGI)
Detection of mechanical stimulus involved in sensory perception of touch GO:0050976
The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal.
1 P91910 (/IMP)
MRNA transport GO:0051028
The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P06606 (/IMP)
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
1 P24634 (/IMP)
Centrosome localization GO:0051642
Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
1 P34690 (/IMP)
Cellular response to gravity GO:0071258
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.
1 P29511 (/IMP)
Cellular response to interleukin-4 GO:0071353
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.
1 P05213 (/IDA)
Establishment or maintenance of cell polarity regulating cell shape GO:0071963
Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell.
1 P04689 (/IMP)
Seed trichome differentiation GO:0090376
The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function.
1 Q8VXK7 (/IEP)
Positive regulation of detection of mechanical stimulus involved in sensory perception of touch GO:1905789
Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch.
1 P91910 (/IGI)
Positive regulation of mechanosensory behavior GO:1905792
Any process that activates or increases the frequency, rate or extent of mechanosensory behavior.
1 P91910 (/IGI)

There are 59 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
11 C9J2C0 (/IDA) F5H5D3 (/IDA) P68363 (/IDA) P68366 (/IDA) Q13748 (/IDA) Q1ZYQ1 (/IDA) Q6PEY2 (/IDA) Q71U36 (/IDA) Q9BQE3 (/IDA) Q9NY65 (/IDA)
(1 more)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
10 P04689 (/IDA) P05213 (/IDA) P05214 (/IDA) P29511 (/IDA) P32255 (/IDA) P68363 (/IDA) P68366 (/IDA) P87066 (/IDA) P91910 (/IDA) Q71U36 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 P04689 (/IDA) P06603 (/IDA) P06606 (/IDA) Q13748 (/IDA) Q6PEY2 (/IDA) Q6ZLZ9 (/IDA) Q71U36 (/IDA) Q9BQE3 (/IDA)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
6 P05213 (/ISO) P05214 (/ISO) P68368 (/ISO) P68369 (/ISO) P68373 (/ISO) Q9JJZ2 (/ISO)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
5 P06603 (/ISS) P06604 (/ISS) P06605 (/ISS) P06606 (/ISS) Q9VED6 (/ISS)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
5 P68363 (/TAS) P68370 (/TAS) Q4GYY5 (/TAS) Q71U36 (/TAS) Q9BQE3 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 B5DGE8 (/IDA) B5DH02 (/IDA) P68363 (/IDA) P68366 (/IDA) Q71U36 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P05213 (/TAS) P68366 (/TAS) P81947 (/TAS) Q71U36 (/TAS)
Cytoplasmic microtubule GO:0005881
Any microtubule in the cytoplasm of a cell.
4 P05213 (/IDA) P24633 (/IDA) P68369 (/IDA) P68373 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P05214 (/ISO) P68369 (/ISO) P68373 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P04689 (/IDA) P11139 (/IDA) P29511 (/IDA)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
3 P05213 (/ISO) P68368 (/ISO) P68369 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P06606 (/IDA) P11139 (/IDA) P29511 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
3 P05213 (/IDA) P68369 (/IDA) P68370 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
3 P68370 (/IDA) Q6AYZ1 (/IDA) Q6P9V9 (/IDA)
Tubulin complex GO:0045298
A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.
3 P09734 (/IGI) P24633 (/IGI) P87066 (/IGI)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 P06603 (/IDA) P06605 (/IDA) P06606 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P05213 (/ISO) P68368 (/ISO) P68369 (/ISO)
Astral microtubule GO:0000235
Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.
2 P04688 (/NAS) P04689 (/NAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P06603 (/IDA) P06606 (/IDA)
Spindle pole body GO:0005816
The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.
2 P09733 (/IDA) P09734 (/IDA)
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
2 P06603 (/IDA) P87066 (/IDA)
Kinetochore microtubule GO:0005828
Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.
2 P09733 (/IC) P09734 (/IC)
Nuclear microtubule GO:0005880
Any microtubule in the nucleus of a cell.
2 P09733 (/IC) P09734 (/IC)
Cytoplasmic microtubule GO:0005881
Any microtubule in the cytoplasm of a cell.
2 P09733 (/IC) P09734 (/IC)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 O18688 (/IDA) P91910 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 O18688 (/IDA) P91910 (/IDA)
Tubulin complex GO:0045298
A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.
2 P09733 (/IDA) P29511 (/IDA)
Astral microtubule GO:0000235
Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.
1 P06603 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P68366 (/TAS)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
1 P29511 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P29511 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 P29511 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 P06603 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 P32255 (/TAS)
Polar microtubule GO:0005827
Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart.
1 P09733 (/IC)
Kinetochore microtubule GO:0005828
Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.
1 P87066 (/IDA)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
1 Q9JJZ2 (/ISA)
Spindle microtubule GO:0005876
Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
1 P04689 (/IDA)
Axonemal microtubule GO:0005879
A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.
1 Q19490 (/IDA)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 P05214 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 P29511 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P29511 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 O18688 (/IDA)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
1 Q5VLK2 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 Q9BQE3 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 P68373 (/ISO)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
1 P09733 (/IDA)
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
1 P05214 (/IDA)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
1 Q71U36 (/IDA)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
1 P68369 (/ISO)
Tubulin complex GO:0045298
A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.
1 P09733 (/IPI)
Tubulin complex GO:0045298
A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.
1 P09734 (/ISA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 P32255 (/IDA)
Cortical microtubule GO:0055028
Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol.
1 P06606 (/IDA)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
1 Q71U36 (/IDA)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
1 P68369 (/ISO)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
1 O18688 (/IDA)
Meiotic spindle GO:0072687
A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.
1 O18688 (/IDA)