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CATH Superfamily 3.30.1130.10

GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
4438
GTP cyclohydrolase I type 1
62311
EC
3D
 1a8rA02 - 87.1
4558
D-erythro-78-dihydroneopterin triphosphate epimerase FolX
53663
EC
3D
 1b9lA00 - 97.1
4489
Dihydroneopterin aldolase FolB, putative
37525
EC
3D
 2o90A00 - 81.5
4553
NADPH-dependent 7-cyano-7-deazaguanine reductase
12877
EC
3D
 3bp1A02 - 99.3
4424
GTP cyclohydrolase 1
7576
EC
 - - 94.1
4535
NADPH-dependent 7-cyano-7-deazaguanine reductase
7555
EC
3D
 3bp1A01 - 94.9
4540
Dihydroneopterin aldolase 2
7104
EC
3D
 1sqlA00 - 95.6
4433
GTP cyclohydrolase 1
5163
EC
3D
 4uqfA02 - 93.0
4407
GTP cyclohydrolase 1
3397
EC
 - - 71.5
4444
GTP cyclohydrolase 1
2854
EC
 - - 92.3
4386
GTP cyclohydrolase 1
1774
EC
3D
 1wm9A02 - 90.0
4249
GTP cyclohydrolase 1 isoform 1
742
EC
3D
 1fb1A02 - 61.7
1567
GTP cyclohydrolase 1
742
EC
 - - 0.9
4542
Dihydroneopterin aldolase
687
EC
 - - 76.5
1924
Dihydroneopterin aldolase
367
EC
3D
 1nbuA00 - 0.0
2102
Bifunctional folate synthesis protein
274
EC
3D
 2cg8A01 - 63.9
4429
GTP cyclohydrolase 1
141
EC
 - - 75.3
1935
Dihydroneopterin aldolase
110
EC
 - - 10.8
1266
GTP cyclohydrolase 1
100
EC
 - - 6.7
3571
GTP cyclohydrolase I
100
EC
 - - 0.0
4246
GTP cyclohydrolase 1
98
EC
 - - 42.1
4374
GTP cyclohydrolase 1
97
EC
 - - 38.5
987
GTP cyclohydrolase 1
91
EC
 - - 1.8
728
GTP cyclohydrolase 1
66
EC
 - - 16.0
3765
NADPH-dependent 7-cyano-7-deazaguanine reductase
54
EC
 - - 8.3
415
GTP cyclohydrolase 1
51
EC
 - - 6.2
2106
Dihydro-6-hydroxymethylpterin pyrophosphokinase
45
EC
 - - 13.1
1056
GTP cyclohydrolase 1
34
EC
 - - 18.6
408
GTP cyclohydrolase 1 2
33
EC
 - - 28.8
4184
GTP cyclohydrolase 1
32
EC
 - - 18.7
4209
GTP cyclohydrolase 1
26
EC
 - - 20.2
4365
Dihydroneopterin aldolase
21
EC
 - - 22.6
734
Putative GTP cyclohydrolase I
15
EC
 - - 13.0
1951
Dihydroneopterin aldolase
13
EC
 - - 15.9
3665
Dihydro-6-hydroxymethylpterin pyrophosphokinase
13
EC
 - - 0.0
3319
NADPH-dependent 7-cyano-7-deazaguanine reductase
10
EC
 - - 0.0
733
GTP cyclohydrolase 1
6
EC
 - - 0.0
4227
GTP cyclohydrolase 1
5
EC
 - - 23.0
3042
Probable dihydroneopterin aldolase
4
EC
 - - 0.0
1435
GTP cyclohydrolase 1
4
EC
 - - 0.0
4493
GTP cyclohydrolase 1
3
EC
 - - 45.6
727
GTP cyclohydrolase 1
3
EC
 - - 10.3
4555
Folic acid synthesis protein fol1
3
EC
 - - 45.9
3880
GTP cyclohydrolase I
2
EC
 - - 14.4
2437
Probable dihydroneopterin aldolase
2
EC
 - - 1.0
4482
GTP cyclohydrolase 1
2
EC
 - - 31.4
3276
GTP cyclohydrolase I
2
EC
 - - 15.0
3028
Folic acid synthesis protein FOL1
1
EC
 - - 0.0