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CATH Superfamily 3.30.1120.30

POLO box domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
POLO box domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 486: Cell cycle serine/threonine-protein kinase CDC5/MS...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Polo kinase. [EC: 2.7.11.21]
ATP + a protein = ADP + a phosphoprotein.
  • The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation.
  • The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein.
  • Formerly EC 2.7.1.37.
 9 A0A0V1Q6B8 A0A1E4RR27 A5DLX5 B9W6P6 C4YFG2 G8B632 H8X287 Q5ABG0 Q6BLX3
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