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CATH Superfamily 3.20.70.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5037: Putative formate acetyltransferase 2

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Formate C-acetyltransferase. [EC: 2.3.1.54]
Acetyl-CoA + formate = CoA + pyruvate.
    		 1800 A0A023YUY0 A0A023YUY0 A0A023Z5P7 A0A023Z5P7 A0A024KPC6 A0A024KPC6 A0A025C1D9 A0A025C1D9 A0A025CDX6 A0A025CDX6
    (1790 more...)
    4-hydroxyphenylacetate decarboxylase. [EC: 4.1.1.83]
    (4-hydroxyphenyl)acetate = 4-methylphenol + CO(2).
    • The enzyme, from the strict anaerobe Clostridium difficile, can also use (3,4-dihydroxyphenyl)acetate as a substrate, yielding 4-methylcatechol as a product.
    • The enzyme is a glycyl radical enzyme.
    		 1072 A0A027TH19 A0A027TH19 A0A027U6R7 A0A027U6R7 A0A027ZQN8 A0A027ZQN8 A0A028AJ31 A0A028AJ31 A0A028E4G3 A0A028E4G3
    (1062 more...)
    Benzylsuccinate synthase. [EC: 4.1.99.11]
    Toluene + fumarate = benzylsuccinate.
    • A glycyl radical enzyme that is inhibited by benzyl alcohol, benzaldehyde, phenylhydrazine and is inactivated by oxygen.
    		 50 A0A064C019 A0A064C019 A0A083ZZW7 A0A083ZZW7 A0A084A637 A0A084A637 A0A0C7F281 A0A0C7F281 A0A0J6DEH0 A0A0J6DEH0
    (40 more...)
    Glycerol dehydratase. [EC: 4.2.1.30]
    Glycerol = 3-hydroxypropanal + H(2)O.
      		 18 A0A010ZN87 A0A010ZN87 B6E975 B6E975 D4LJT1 D4LJT1 D4LR06 D4LR06 D4M2Z8 D4M2Z8
      (8 more...)
      [Formate-C-acetyltransferase]-activating enzyme. [EC: 1.97.1.4]
      S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical.
      • A single glycine residue in EC 2.3.1.54 is oxidized to the corresponding radical by transfer of H from its CH(2) to AdoMet with concomitant cleavage of the latter.
      • The first stage is reduction of the AdoMet to give methionine and the 5'-deoxyadenosin-5'-yl radical, which then abstracts a hydrogen radical from the glycine residue.
      		 2 A0A0W8FLS9 A0A0W8FLS9
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