The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol (PI) phosphodiesterase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7599: Phospholipase D LiSicTox-betaID1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phospholipase D. [EC: 3.1.4.4]
A phosphatidylcholine + H(2)O = choline + a phosphatidate.
  • Also acts on other phosphatidyl esters.
414 A0A0N1SIW0 A0A0N1SIW0 A4USB4 A4USB4 B2KKV6 B2KKV6 B2KKV7 B2KKV7 B2KKV8 B2KKV8
(404 more...)
Sphingomyelin phosphodiesterase D. [EC: 3.1.4.41]
Sphingomyelin + H(2)O = ceramide phosphate + choline.
  • Does not act on phosphatidylcholine, but hydrolyzes 2-lysophosphatidylcholine to choline and 2-lysophosphatidate.
10 B7PW58 B7PW58 B7Q3W8 B7Q3W8 C7SZ47 C7SZ47 Q202J4 Q202J4 Q59121 Q59121
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