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CATH Superfamily 3.20.20.150

Divalent-metal-dependent TIM barrel enzymes

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Divalent-metal-dependent TIM barrel enzymes
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10569: Xylose isomerase-like TIM barrel

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Xylose isomerase. [EC: 5.3.1.5]
D-xylopyranose = D-xylulose.
  • The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity.
  • The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites.
  • Isomerization proceeds via a hydride-shift mechanism.
 663 A0A011TYT0 A0A014MDQ7 A0A021VT52 A0A022LDW0 A0A022MAK3 A0A024H241 A0A024QXA4 A0A031FVX7 A0A034UJ87 A0A060JB49
(653 more...)