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CATH Superfamily 3.20.20.140

Metal-dependent hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Metal-dependent hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 40798: Dihydroorotase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dihydroorotase. [EC: 3.5.2.3]
(S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate.
    		 2692 A0A011DPS9 A0A011DPS9 A0A013M8F1 A0A013M8F1 A0A022IZX6 A0A022IZX6 A0A023BXY7 A0A023BXY7 A0A023E6V3 A0A023E6V3
    (2682 more...)
    Allantoinase. [EC: 3.5.2.5]
    (S)-allantoin + H(2)O = allantoate.
      		 2 A0A1J5SWF8 A0A1J5SWF8
      Carbamoyl-phosphate synthase (glutamine-hydrolyzing). [EC: 6.3.5.5]
      2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.
      • The product carbamoyl phosphate is an intermediate in the biosynthesis of arginine and the pyrimidine nucleotides.
      • The enzyme from Escherichia coli has three separate active sites, which are connected by a molecular tunnel that is almost 100 A in length.
      • The amidotransferase domain within the small subunit of the enzyme hydrolyzes glutamine to ammonia via a thioester intermediate.
      • The ammonia migrates through the interior of the protein, where it reacts with carboxyphosphate to produce the carbamate intermediate.
      • The carboxyphosphate intermediate is formed by the phosphorylation of hydrogencarbonate by ATP at a site contained within the N-terminal half of the large subunit.
      • The carbamate intermediate is transported through the interior of the protein to a second site within the C-terminal half of the large subunit, where it is phosphorylated by another ATP to yield the final product, carbamoyl phosphate.
      • Cf. EC 6.3.4.16.
      • Formerly EC 2.7.2.9.
      		 2 B9WMA6 B9WMA6
      Aspartate carbamoyltransferase. [EC: 2.1.3.2]
      Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
        		 2 B9WMA6 B9WMA6
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