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CATH Superfamily 3.20.20.140

Metal-dependent hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Metal-dependent hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 40708: 2,3-dihydroxybenzoate decarboxylase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aminocarboxymuconate-semialdehyde decarboxylase. [EC: 4.1.1.45]
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO(2).
  • The product rearranges non-enzymically to picolinate.
 162 A0A017HLX3 A0A017HLX3 A0A061D5B5 A0A061D5B5 A0A068N715 A0A068N715 A0A072NNK0 A0A072NNK0 A0A075HPH1 A0A075HPH1
(152 more...)
O-pyrocatechuate decarboxylase. [EC: 4.1.1.46]
2,3-dihydroxybenzoate = catechol + CO(2).
    		 20 A0A084FWN0 A0A084FWN0 A0A0D9MSH7 A0A0D9MSH7 A0A0N1GZ58 A0A0N1GZ58 A2QMG8 A2QMG8 A2RA03 A2RA03
    (10 more...)
    Salicylate decarboxylase. [EC: 4.1.1.91]
    Salicylate = phenol + CO(2).
    • In the reverse direction the enzyme catalyzes the regioselective carboxylation of phenol into stoichiometric amounts of salicylate.
    • The enzyme also catalyzes the reversible decarboxylation of 2,4- dihydroxybenzoate, 2,6-dihydroxybenzoate, 2,3-dihydroxybenzoate and 4-aminosalicylate.
    		 2 P0CT50 P0CT50
    3-hydroxyanthranilate 3,4-dioxygenase. [EC: 1.13.11.6]
    3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde.
    • The product of the reaction spontaneously rearrange to quinolinic acid (quin).
    • Formerly EC 1.13.1.6.
    		 2 Q6W752 Q6W752
    Tryptophan 2,3-dioxygenase. [EC: 1.13.11.11]
    L-tryptophan + O(2) = N-formyl-L-kynurenine.
    • Catalyzes, together with EC 1.13.11.52, the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.
    • Specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan.
    • Formerly EC 1.11.1.4 and EC 1.13.1.12.
    		 2 Q1ITW3 Q1ITW3
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