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CATH Superfamily 3.20.20.140

Metal-dependent hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Metal-dependent hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 40304: Peptidase M19, renal dipeptidase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Membrane dipeptidase. [EC: 3.4.13.19]
Hydrolysis of dipeptides.
  • Membrane bound, with broad specificity.
  • Abundant in the kidney cortex.
  • Inhibited by bestatin and cilastatin.
  • Belongs to peptidase family M19.
  • Formerly EC 3.4.3.1, EC 3.4.3.2, EC 3.4.3.6, EC 3.4.13.1, EC 3.4.13.2, EC 3.4.13.8, EC 3.4.13.11 and EC 3.4.13.15.
 2984 A0A010Q9Q0 A0A010Q9Q0 A0A010RA26 A0A010RA26 A0A017S8S4 A0A017S8S4 A0A022VMS9 A0A022VMS9 A0A022W1D8 A0A022W1D8
(2974 more...)
L-lactate dehydrogenase. [EC: 1.1.1.27]
(S)-lactate + NAD(+) = pyruvate + NADH.
  • Also oxidizes other (S)-2-hydroxymonocarboxylic acids.
  • NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.
 2 A0A0L1HSC1 A0A0L1HSC1
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