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CATH Superfamily 3.20.20.120

Enolase-like C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Enolase-like C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7511: o-succinylbenzoate synthase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
O-succinylbenzoate synthase. [EC: 4.2.1.113]
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H(2)O.
  • Forms part of the vitamin-K biosynthesis pathway.
 2854 A0A011NEL8 A0A011NEL8 A0A014MAE2 A0A014MAE2 A0A017IEP5 A0A017IEP5 A0A022PAW8 A0A022PAW8 A0A023EBU6 A0A023EBU6
(2844 more...)
Carboxylesterase. [EC: 3.1.1.1]
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
  • Wide specificity; also hydrolyzes vitamin A esters.
  • The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4, and EC 3.5.1.13.
  • Formerly EC 3.1.1.12.
 2 B9RLD6 B9RLD6
Muconate cycloisomerase. [EC: 5.5.1.1]
(+)-muconolactone = cis,cis-muconate.
  • Also acts, in the reverse reaction, on 3-methyl-cis,cis-muconate and, very slowly, on cis,trans-muconate.
  • Not identical with EC 5.5.1.7 or EC 5.5.1.11.
 2 A0A0T9QR09 A0A0T9QR09
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. [EC: 4.2.99.20]
5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.
  • Involved in the biosynthesis of vitamin K2 (menaquinone).
  • In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival.
  • It had previously been thought that the reactions carried out by this enzyme and EC 2.2.1.9 were carried out by a single enzyme but this has since been disproved.
  • Formerly EC 2.5.1.64 and EC 4.2.99.n1.
 2 Q15KI9 Q15KI9
Isochorismate synthase. [EC: 5.4.4.2]
Chorismate = isochorismate.
  • The reaction is reversible.
  • Formerly EC 5.4.99.6.
 2 A0A0B2SJQ1 A0A0B2SJQ1
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase. [EC: 2.2.1.9]
Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl- cyclohex-3-ene-1-carboxylate + CO(2).
  • Involved in the biosynthesis of vitamin K(2) (menaquinone).
  • In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival.
  • It had previously been thought that the products of the reaction were (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate (SHCHC), pyruvate and CO(2) but it is now known that two separate enzymes are involved: this enzyme and EC 4.2.99.20.
  • Under basic conditions, the product can spontaneously lose pyruvate to form SHCHC.
  • Formerly EC 2.5.1.64 and EC 2.5.1.n1.
 2 Q15KI9 Q15KI9
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