The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Enolase-like C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 249: Enolase 2, putative, expressed

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphopyruvate hydratase. [EC: 4.2.1.11]
2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.
  • Also acts on 3-phospho-D-erythronate.
199 A0A023AWY9 A0A023AY94 A0A023B3P4 A0A023B9I5 A0A024R4F1 A0A024V5N5 A0A024VQJ1 A0A024W8D8 A0A024WQ82 A0A060RYD7
(189 more...)
U-plasminogen activator. [EC: 3.4.21.73]
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
  • Formed from the inactive precursor by action of plasmin or plasma kallikrein.
  • Differs in structure from EC 3.4.21.68, and does not bind to fibrin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.31 and EC 3.4.99.26.
1 E3TF25
T-plasminogen activator. [EC: 3.4.21.68]
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
  • From a wide variety of mammalian tissues, especially endothelial cells.
  • Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin.
  • Activity is considerably enhanced by fibrin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.31 and EC 3.4.99.26.
1 E3TF25
Acetyl-CoA C-acyltransferase. [EC: 2.3.1.16]
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
    1 Q6RIB7