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CATH Superfamily 3.20.20.100

NADP-dependent oxidoreductase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15071: L-galactose dehydrogenase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
D-arabinose 1-dehydrogenase (NAD(+)). [EC: 1.1.1.116]
D-arabinose + NAD(+) = D-arabinono-1,4-lactone + NADH.
    		 12 A0A0L8VJT9 B3LLU0 B5VPH1 C7GL78 C8ZEP8 E7KGH7 E7KSI6 E7LYC1 E7QJ53 H0GM05
    (2 more...)
    D-threo-aldose 1-dehydrogenase. [EC: 1.1.1.122]
    A D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + NADH.
    • Acts on L-fucose, D-arabinose and L-xylose.
    • The animal enzyme was also shown to act on L-arabinose, and the enzyme from Pseudomonas caryophylli on L-glucose.
    		 4 A0A0B2SPQ2 A0A151SI52 C6TI51 Q52472
    Pyridoxal 4-dehydrogenase. [EC: 1.1.1.107]
    Pyridoxal + NAD(+) = 4-pyridoxolactone + NADH.
    • The enzyme acts on the hemiacetal form of the substrate.
    		 3 A6WVT4 B9RX35 Q76KC2
    L-galactose 1-dehydrogenase. [EC: 1.1.1.316]
    L-galactose + NAD(+) = L-galactono-1,4-lactone + NADH.
    • The enzyme catalyzes a step in the ascorbate biosynthesis in higher plants (Smirnoff-Wheeler pathway).
    • The activity with NADP(+) is less than 10% of the activity with NAD(+).
    		 2 A0A178USL2 O81884
    L-galactonolactone dehydrogenase. [EC: 1.3.2.3]
    L-galactono-1,4-lactone + 4 ferricytochrome c = L-dehydroascorbate + 4 ferrocytochrome c + 4 H(+).
    • Catalyzes the final step in the biosynthesis of L-ascorbic acid in higher plants and in nearly all higher animals with the exception of primates and some birds.
    • Very specific for its substrate L-galactono-1,4-lactone as D-galactono-gamma-lactone, D-gulono-gamma-lactone, L-gulono-gamma- lactone, D-erythronic-gamma-lactone, D-xylonic-gamma-lactone, L-mannono-gamma-lactone, D-galactonate, D-glucuronate and D-gluconate are not substrates.
    • FAD, NAD(+), NADP(+) and O(2) (cf. EC 1.3.3.12) cannot act as electron acceptor.
    		 1 Q07A10
    D-galactose 1-dehydrogenase. [EC: 1.1.1.48]
    D-galactose + NAD(+) = D-galactono-1,4-lactone + NADH.
    • This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
    		 1 C3S7Q9
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