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CATH Superfamily 3.20.20.100

NADP-dependent oxidoreductase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15070: 2,5-diketo-D-gluconic acid reductase

There are 16 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming). [EC: 1.1.1.274]
2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH.
  • The enzyme is involved in the catabolism of 2,5-didehydrogluconate.
  • cf. EC 1.1.1.346.
 2238 A0A009GMV4 A0A009GMV4 A0A009KDC7 A0A009KDC7 A0A010KYZ8 A0A010KYZ8 A0A010RPP6 A0A010RPP6 A0A010UX28 A0A010UX28
(2228 more...)
2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming). [EC: 1.1.1.346]
2-dehydro-L-gulonate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH.
  • The enzyme is involved in ketogluconate metabolism, and catalyzes the reaction in vivo in the reverse direction to that shown.
  • It is used in the commercial microbial production of ascorbate.
  • cf. EC 1.1.1.274.
 254 A0A026UR25 A0A026UR25 A0A029L3E7 A0A029L3E7 A0A029PYM9 A0A029PYM9 A0A066PQY0 A0A066PQY0 A0A069XJ26 A0A069XJ26
(244 more...)
Aldehyde reductase. [EC: 1.1.1.21]
Alditol + NAD(P)(+) = aldose + NAD(P)H.
  • Wide specificity.
  • Formerly EC 1.1.1.139.
 230 A0A023B129 A0A023B129 A0A026RNE3 A0A026RNE3 A0A026UR25 A0A026UR25 A0A029IDJ1 A0A029IDJ1 A0A029J2E2 A0A029J2E2
(220 more...)
Methylglyoxal reductase (NADPH). [EC: 1.1.1.283]
(S)-lactaldehyde + NADP(+) = 2-oxopropanal + NADPH.
  • The enzyme from the yeast Saccharomyces cerevisiae catalyzes the reduction of a keto group in a number of compounds, forming enantiopure products.
  • Among the substrates are methylglyoxal (which is reduced to (S)- lactaldehyde), 3-methylbutanal, hexane-2,5-dione and 3-chloro-1- phenylpropan-1-one.
  • The enzyme differs from EC 1.1.1.78 which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference.
 12 A0A074TDJ8 A0A074TDJ8 A0A086KXA0 A0A086KXA0 A0A125YUR9 A0A125YUR9 A0A139Y5P2 A0A139Y5P2 B6KDS0 B6KDS0
(2 more...)
Indole-3-acetaldehyde reductase (NADPH). [EC: 1.1.1.191]
(Indol-3-yl)ethanol + NADP(+) = (indol-3-yl)acetaldehyde + NADPH.
    		 10 A0A084G8Z5 A0A084G8Z5 A0A0F8CS81 A0A0F8CS81 A0A0F8D3I3 A0A0F8D3I3 M5CDA7 M5CDA7 O13848 O13848
    2-dehydropantolactone reductase (Re-specific). [EC: 1.1.1.168]
    (R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH.
    • The enzyme from Saccharomyces cerevisiae differs from that from Escherichia coli (EC 1.1.1.214), which is specific for the Si-face of NADP, and in receptor requirements from EC 1.1.99.26.
    		 8 G8B620 G8B620 G8BKT7 G8BKT7 Q76L36 Q76L36 Q76L37 Q76L37
    1-deoxy-D-xylulose-5-phosphate reductoisomerase. [EC: 1.1.1.267]
    2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
    • The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
    • The mechanism has been shown to be a retroaldol/aldol reaction.
    		 8 F7PHK7 F7PHK7 F7PMX7 F7PMX7 U2E4S5 U2E4S5 U2F812 U2F812
    20-alpha-hydroxysteroid dehydrogenase. [EC: 1.1.1.149]
    17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha- hydroxyprogesterone + NAD(P)H.
    • Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62).
    		 4 K0KGQ3 K0KGQ3 K0KYW7 K0KYW7
    Indole-3-acetaldehyde reductase (NADH). [EC: 1.1.1.190]
    (Indol-3-yl)ethanol + NAD(+) = (indol-3-yl)acetaldehyde + NADH.
      		 4 A0A084G8Z5 A0A084G8Z5 O13848 O13848
      Carbonyl reductase (NADPH). [EC: 1.1.1.184]
      R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
      • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
      • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
      		 4 A0A161HI83 A0A161HI83 Q6CL47 Q6CL47
      2-dehydropantolactone reductase. [EC: 1.1.1.358]
      (R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH.
      • The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B(5)).
      • This entry covers enzymes whose stereo specificity for NADP(+) is not known (cf. EC 1.1.1.168 and EC 1.1.1.214).
      		 4 G8BKT7 G8BKT7 Q76L36 Q76L36
      Aryl-alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.91]
      An aromatic alcohol + NADP(+) = an aromatic aldehyde + NADPH.
      • Also acts on some aliphatic aldehydes, but cinnamaldehyde was the best substrate found.
      		 2 Q88KC2 Q88KC2
      Prostaglandin-F synthase. [EC: 1.1.1.188]
      (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.
      • Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2).
      • Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
      		 2 D1NWM2 D1NWM2
      Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.2]
      An alcohol + NADP(+) = an aldehyde + NADPH.
      • Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.
      • May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.
      • Re-specific with respect to NADPH.
      		 2 F7PH13 F7PH13
      3-alpha-hydroxysteroid dehydrogenase (Re-specific). [EC: 1.1.1.213]
      A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
      • The enzyme acts on multiple 3-alpha-hydroxysteroids.
      • Re-specific with respect to NAD(+) or NADP(+) (cf. EC 1.1.1.50).
      • Enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known are described by EC 1.1.1.357.
      		 2 A0A0H3KPN5 A0A0H3KPN5
      Morphine 6-dehydrogenase. [EC: 1.1.1.218]
      Morphine + NAD(P)(+) = morphinone + NAD(P)H.
      • Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine.
      • In the reverse direction, also reduces naloxone to the 6-alpha- hydroxy analog.
      • Activated by 2-mercaptoethanol.
      		 2 C7HSP7 C7HSP7
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