The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15062: Oxidoreductase, aldo/keto reductase family

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
20-alpha-hydroxysteroid dehydrogenase. [EC: 1.1.1.149]
17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha- hydroxyprogesterone + NAD(P)H.
  • Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62).
1 E1SBQ1
Versiconal hemiacetal acetate reductase. [EC: 1.1.1.353]
(1) Versicolorone + NADP(+) = 1'-hydroxyversicolorone + NADPH. (2) Versiconol acetate + NADP(+) = versiconal hemiacetal acetate + NADPH. (3) Versiconol + NADP(+) = versiconal + NADPH.
  • Isolated from the mold Aspergillus parasiticus.
  • Involved in a metabolic grid that leads to aflatoxin biosynthesis.
1 A0A0H4NVF3
GMP reductase. [EC: 1.7.1.7]
Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.
  • Formerly EC 1.6.6.8.
1 A8T4B3
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